中国癌症杂志2025，Vol.35Issue(6)：585-591,7.DOI:10.19401/j.cnki.1007-3639.2025.06.008
病毒样颗粒在肿瘤治疗中的应用研究进展及展望
Research progress and prospects of virus-like particles in tumor therapy
刘春 1陈国心 1李梦甜 1赵钰 2马忠仁 1张海霞3
作者信息
- 1. 西北民族大学细胞基质疫苗关键技术与产业化教育部工程研究中心,甘肃 兰州 730030||西北民族大学生物医学研究中心,生物工程与技术国家民委重点实验室,甘肃 兰州 730030
- 2. 西北民族大学生物医学研究中心,生物工程与技术国家民委重点实验室,甘肃 兰州 730030||西北民族大学生物医学研究中心,甘肃省动物细胞技术创新中心,甘肃 兰州 730030
- 3. 西北民族大学细胞基质疫苗关键技术与产业化教育部工程研究中心,甘肃 兰州 730030||西北民族大学生物医学研究中心,生物工程与技术国家民委重点实验室,甘肃 兰州 730030||西北民族大学生物医学研究中心,甘肃省动物细胞技术创新中心,甘肃 兰州 730030
- 折叠
摘要
Abstract
Virus-like particles(VLPs)are hollow nanoparticles composed of one or several virus structural proteins,which have a morphological structure similar to natural viruses but do not contain any genetic material.Due to the excellent innate immunogenicity and safety of VLPs,they are often used in the development of tumor vaccines.In addition,compared with traditional drug delivery vectors,VLPs have better biocompatibility and strong targeting ability,making them highly valued in the delivery of anti-tumor drugs.In recent years,the efficient delivery of gene editing tools using VLPs has provided new possibilities for tumor treatment.VLPs can inhibit tumor growth and spread through various mechanisms,such as activating immune responses to suppress tumor growth,stimulating the body's immune system,promoting the expression of tumor associated antigens,and enhancing the body's ability to recognize and clear tumor cells.These studies not only broaden the application scope of VLPs in the field of anti-tumor therapy,but also provide a broader prospect for future research and application.This article reviewed the research progress of VLPs derived from different viruses in preventive or therapeutic vaccines and drug delivery carriers,and explored new development strategies.关键词
病毒样颗粒/药物递送载体/抗肿瘤药物/肿瘤疫苗Key words
Virus-like particles/Drug delivery vehicles/Antitumor drug/Tumor vaccine分类
医药卫生引用本文复制引用
刘春,陈国心,李梦甜,赵钰,马忠仁,张海霞..病毒样颗粒在肿瘤治疗中的应用研究进展及展望[J].中国癌症杂志,2025,35(6):585-591,7.
