中国临床药理学杂志2025，Vol.41Issue(9)：1218-1222,5.DOI:10.13699/j.cnki.1001-6821.2025.09.004
基于治疗药物监测的奥卡西平活性代谢物剂量校正浓度影响因素分析
Analysis of influencing factors of dose-corrected concentration of the active metabolites of oxcarbazepine based on therapeutic drug monitoring
摘要
Abstract
Objective To investigate the influencing factors of the dose-corrected concentration(C/D)of the active metabolite of oxcarbazepine(OXC)[10-hydroxycarbazepine(MHD)]and to provide the reference for the rational clinical use of this drug.Methods A total of 161 MHD blood concentrations were collected from the therapeutic drug monitoring(TDM)data of inpatients who received OXC treatment,as well as demographic information,comedications,diagnosis,and associated clinical chemistry results.Data analysis was carried out through the SPSS 27.0 software.Results The effects of age,body mass index(BMI),comedications and diagnosis on MHD C/D values were statistically significant(all P＜0.05).The C/D value of patients under 18 years old was higher than that of patients between 18 to 65 years old.The C/D value of female patients was higher than that of male patients in adults.The C/D value of the underweight group was higher than the normal,overweight and obese groups.The C/D value of patients combined with valproic acid was significantly lower than that of patients who didn't.The C/D value of epilepsy patients was significantly lower than that of patients who weren't diagnosed with this disease.Only 11 patients(8.20％)had blood sodium below the normal value range after medication,and there was no significant difference in blood sodium value,serum creatinine value,and glutamic-pyruvic transaminase value before and after treatment(all P＞0.05).The results of multiple linear regression analysis showed that BMI had an effect on the C/D of MHD(P＜0.05).Conclusion OXC has relatively good safety profile,and the effects of gender,age,BMI,comedications and diagnosis should be taken into consideration when OXC is prescribed.关键词
奥卡西平代谢物/治疗药物监测/剂量校正浓度/影响因素Key words
metabolite of oxcarbazepine/therapeutic drug monitoring/dose-corrected concentration/influencing factor分类
医药卫生引用本文复制引用
罗雅,邓国卫,尚德为,温预关,胡晋卿..基于治疗药物监测的奥卡西平活性代谢物剂量校正浓度影响因素分析[J].中国临床药理学杂志,2025,41(9):1218-1222,5.基金项目
广东省科技创新战略专项资金资助项目(2018A0303130074) （2018A0303130074）
广州市医学重点学科基金资助项目(2025-2027年) （2025-2027年）
