中国中医眼科杂志2025，Vol.35Issue(7)：635-640,663,7.DOI:10.13444/j.cnki.zgzyykzz.2025.07.006
基于数据挖掘探讨中医古籍治疗睑弦赤烂的用药规律
Exploring the Medication Patterns for Treating Marginal Blepharitis in Ancient Chi-nese Medical Texts Based on Data Mining
摘要
Abstract
OBJECTIVE To analyze the medication patterns for treating reddish eyelid margin in ancient Chinese medical books using data mining technology,providing clinical insights and medication experience for its treatment.METHODS Prescriptions for reddish eyelid margin from 16 ancient Chinese medical texts,including Yin Hai Jing Wei and Zheng Zhi Zhun Sheng·Ophthalmology,were included.After standardizing the names of Chinese medicines,a database was established in Excel 2019 software.The Traditional Chinese Medicine Inheritance Computing Platform V3.5 was used to analyze herb properties,frequency of use,efficacy classification,cluster analysis,and association rules.RESULTS(1)properties of Chinese medicines:Among the 16 included ancient books,there were 59 prescriptions involving 121 Chinese medicines with a cumulative frequency of 378 times.Fourteen high-frequency Chinese medicines(used≥10 times)were identified.In terms of the four Qi properties,cold-natured Chinese medicines(179 times,47.35%)were most common.Among the five flavors,bitter Chinese medicines(188 times,35.01%)predominated.Liver meridian(20 times,20.91%)was the most frequently targeted.(2)Frequency of Chinese medicines use:The top six Chinese medicines were Saposhnikovia divaricata(24 times,6.35%),Coptis chinensis(19 times,5.03%),Notopterygium incisum(17 times,4.50%),Schizonepeta tenuifolia,Glycyrrhiza uralensis,and Angelica sinensis(16 times each,4.23%).(3)Chinese medicines efficacy classification:Heat-clearing Chinese medicines(108 times,28.57%)were most common,followed by exterior-releasing Chinese medicines(101 times,26.72%)and tonifying Chinese medicines(49 times,12.96%).(4)Chinese medicines cluster analysis:Four prescription groups were identified with the following effects.They were warming and tonifying liver-kidney while purging fire and drying dampness;Clearing heat and detoxifying while reducing swelling and removing necrosis;Dispelling wind and releasing exterior while clearing heat and detoxifying;Dispelling wind and releasing exterior while promoting Qi and blood circulation.(5)Chinese medicines association analysis:The top five Chinese medicines associations were Notopterygium incisum and Glycyrrhiza uralensis-Saposhnikovia divaricata;Glycyrrhiza uralensis-Saposhnikovia divaricata;Schizonepeta tenuifolia-Saposhnikovia divaricata;Rheum palmatum-Saposhnikovia divaricata;Glycyrrhiza uralensis and Ligusticum chuanxiong-Saposhnikovia divaricata.CONCLUSIONS Ancient physicians treated reddish eyelid margin by addressing deficiency-excess and cold-heat patterns,combining internal and external therapies,while emphasizing liver-lung regulation and spleen-stomach protection.The main treatment strategies included dispelling wind,clearing heat,resolving dampness,relieving pain,and harmonizing blood,with frequent use of mineral-based Chinese medicines.关键词
睑弦赤烂/中医古籍/用药规律/关联规则Key words
marginal blepharitis/ancient Chinese medical books/medication patterns/asso-ciation rules分类
医药卫生引用本文复制引用
陈竹鹏,罗燕,郑博元,沈传焱..基于数据挖掘探讨中医古籍治疗睑弦赤烂的用药规律[J].中国中医眼科杂志,2025,35(7):635-640,663,7.基金项目
云南省科技厅基金项目(202301AZ070001-072) （202301AZ070001-072）
