癌变·畸变·突变2025，Vol.37Issue(4)：314-318,5.DOI:10.3969/j.issn.1004-616x.2025.04.015
局部晚期食管鳞癌患者癌组织SATB1和PRKDC蛋白表达与放化疗敏感性的关系
Expression of SATB1 and PRKDC proteins and sensitivity of advanced esophageal squamous cell carcinomas to chemotherapy
摘要
Abstract
OBJECTIVE:To study the expressions of special AT rich sequence binding protein-1(SATB1)and catalytic subunit of the DNA-dependent protein kinase(PRKDC)protein in advanced esophageal squamous cell carcinomas and their relationship with carcinomas'sensitivity to chemoradiotherapy.METHODS:Thirty patients with locally advanced esophageal squamous cell carcinoma in our hospital were selected as the study subjects.These patients received standard radical radiotherapy and synchronous chemotherapy.Three months after the completion of chemoradiotherapy,the short-term efficacy was evaluated according to the Criteria(RECIST)which classified the patients into two groups:radiotherapy sensitive group(CR+PR)of 16 cases and a chemoradiotherapy insensitive group(SD+PD)of 14 cases.Simultaneously,clinical data such as patient gender,age,pathological grading,clinical staging,tumor location,and survival status were collected.Western Blot assay was used to detect the expression levels of SATB1 and PRKDC proteins in cancer tissues of the patients.Relationships between the expression levels and clinical pathological factors were determined.RESULTS:The PRKDC protein was not expressed in both the sensitive and insensitive groups of carcinomas.Expression levels of SATB1 were higher in the sensitive than the insensitive group(P<0.05).Compared with the insensitive group,the sensitive group had lower tumor differentiation and earlier staging(P<0.05).There was no statistically significant difference in gender,age,lesion location,and 1-year survival between the sensitive and the insensitive groups(P>0.05).CONCLUSION:Our data shows that expression of the SATB1 protein was closely related to the sensitivity of esophageal carcinomas to chemoradiotherapy and to the degree of differentiation.The expression may therefore be useful in predicting efficacy of esophageal carcinomas to chemoradiotherapy.On the other hand,PRKDC protein was not expressed in the cancer tissues.关键词
特异性AT富集序列结合蛋白1/DNA依赖性蛋白激酶催化亚基/食管癌/放化疗敏感性Key words
SATB1/PRKDC/esophageal cancer/chemoradiosensitivity分类
医药卫生引用本文复制引用
阿衣古丽·哈热,阿布地力·阿布都许库..局部晚期食管鳞癌患者癌组织SATB1和PRKDC蛋白表达与放化疗敏感性的关系[J].癌变·畸变·突变,2025,37(4):314-318,5.基金项目
新疆维吾尔自治区自然科学基金(2022D01C301) （2022D01C301）
