阿尔茨海默病及相关病2025，Vol.8Issue(4)：219-225,230,8.DOI:10.3969/j.issn.2096-5516.2025.04.001
阿尔茨海默病深层病理初探及相应的治疗策略
Perspectives on the profound pathological mechanisms of Alzheimer's disease and the corresponding treatment strategies
林勇 1顾柏俊2
作者信息
- 1. 复旦大学华山医院国家老年疾病临床研究中心,上海 200032
- 2. 澳大利亚天然吞噬实验室,墨尔本 3000
- 折叠
摘要
Abstract
There have been many different opinions on the pathogenesis of Alzheimer's disease(AD),and the β-amyloid protein(Aβ)theory has always been dominant.However,many treatments targeting on Aβ have had little effect,which has led researchers to re-examine this theory.More and more research findings have made people realize that although the accumulation of Aβ plaques in the brain is closely related to cognitive decline,it may only be a manifestation of AD,not the root cause of this disease.The body's inability to clear the accumulation of proteins including Aβ due to various reasons such as chronic inflammation with brain damage may be a deeper cause of this disease.These important cell functions include endocytosis,macropinocytosis,innate phagocytosis and autophagy,and mitochondria that provide energy to these high-energy consumption applications may be the determining factor affecting these functions.Therefore,simply removing Aβ plaques may have little effect in the treatment of Alzheimer's disease.More efforts should be placed on how to improve essential cell functions like innate phagocytosis and autophagy,as well as to improve mitochondrial function to increase energy production.关键词
阿尔茨海默病/Aβ理论/天然吞噬/自噬/线粒体/能量代谢Key words
Alzheimer's disease/Aβ theory/Innate phagocytosis/Autophagy/Mitochondrial/Energy metabolism分类
医药卫生引用本文复制引用
林勇,顾柏俊..阿尔茨海默病深层病理初探及相应的治疗策略[J].阿尔茨海默病及相关病,2025,8(4):219-225,230,8.
