阿尔茨海默病及相关病2025，Vol.8Issue(4)：231-238,8.DOI:10.3969/j.issn.2096-5516.2025.04.003
基于静息态功能磁共振对遗忘型轻度认知障碍及阿尔茨海默病患者压后皮层与海马亚区之间功能连接改变的分析
Altered functional connectivity between the retrosplenial cortex and hippocampal subfields in amnestic mild cognitive impairment and Alzheimer's disease
摘要
Abstract
Objective:The aim of the current study was to explore the specific intrinsic functional connectivity between the the retrosplenial cortex(RSC)and the hippocampal subfields in healthy adults and to characterize the alterations in functional connectivity between the RSC and the hippocampal subfields in amnestic mild cognitive impairment(aMCI)and Alzheimer's disease(AD)patients.Methods:Demographic data,neuropsychological assessments,and resting-state functional magnetic resonance imaging(fMRI)data were collected from 60 AD participants,60 participants with aMCI,and 60 sex-matched normal controls(NCs).The bilateral RSC,other parts of the posterior cingulate cortex(PCC),and hippocampus(HPC)subfields(including the bilateral cornu ammonis fields(CA1-CA3),the dentate gyrus(DG),and subiculum(SUB))were selected to investigate functional connectivity alterations in aMCI and AD.Results:Resting-state functional connectivity analysis demonstrated heterogeneity in the degree of connectivity between the HPC and different parts of the total PCC,with considerably greater functional connectivity of the RSC with the HPC compared with other parts of the PCC.Furthermore,the bilateral RSC exhibited widespread intrinsic functional connectivity with all HPC subfields.Compared to the NCs,the aMCI and AD groups showed different magnitudes of decreased functional connectivity between the RSC and the contralateral DG.Additionally,diminished functional connectivity between the left RSC and right DG was correlated with clinical disease severity in aMCI subjects.Conclusion:These findings confirm and extend previous studies suggesting that the RSC is extensively and functionally connected with HPC subfields and that these functional connections are selectively affected in the AD continuum,with prominent disruptions in functional connectivity between the RSC and contralateral DG underpinning episodic memory impairment associated with the disease..关键词
阿尔茨海默病/遗忘型轻度认知障碍/静息态功能磁共振成像/压后皮层/海马亚区Key words
Alzheimer's disease/Amnestic mild cognitive impairment/Resting-state functional magnetic resonance imaging/Retrosplenial cortex/Hippocampal subfields分类
医药卫生引用本文复制引用
王军凯,白昕悦,刘水,陈晓浚,王志群..基于静息态功能磁共振对遗忘型轻度认知障碍及阿尔茨海默病患者压后皮层与海马亚区之间功能连接改变的分析[J].阿尔茨海默病及相关病,2025,8(4):231-238,8.基金项目
陕西省针药结合重点实验室开放课题(KF202320) （KF202320）
