阿尔茨海默病及相关病2025，Vol.8Issue(4)：259-264,6.DOI:10.3969/j.issn.2096-5516.2025.04.006
星形胶质细胞在血管性痴呆中的作用研究进展
Research progress on the role of astrocytes in vascular dementia
摘要
Abstract
Vascular dementia(VaD)is a severe syndrome of cognitive impairment caused by ischemic stroke,hemorrhagic stroke,and cerebrovascular lesions that cause hypoperfusion of memory,cognitive,and behavioral brain regions.Among the types of dementia,VaD is the second most common cause after Alzheimer's disease,but the pathogenesis of VaD is still unclear.Astrocytes are the most abundant glial cells in the central nervous system.Astrocytes have the ability to produce and release specific neurotransmitters,and express corresponding neurotransmitter receptors,which can respond to a variety of neuroactive substances.In recent years,a large number of studies have been carried out on the role of astrocytes in the central nervous system(CNS),and this article reviews the current role and mechanism of astrocytes in the progression of VaD based on the research background and research significance.We hope to provide a useful reference for understanding the pathogenesis of VaD and exploring new treatment methods and bring new breakthroughs in the treatment of clinical VaD.关键词
血管性痴呆/星形胶质细胞/神经炎症Key words
Vascular dementia/Astrocyte/Neuroinflammation分类
医药卫生引用本文复制引用
赵泳莉,赵维纳,王建行,陈泠羽,陈肖杰,李施雨,焦杨..星形胶质细胞在血管性痴呆中的作用研究进展[J].阿尔茨海默病及相关病,2025,8(4):259-264,6.基金项目
黑龙江省自然科学基金项目(SS2023H005) （SS2023H005）
黑龙江省省属高等学校基本科研费科研项目(2022-KYYWF-0662) （2022-KYYWF-0662）
黑龙江省卫生健康委科研课题(20220303070632) （20220303070632）
牡丹江医学院附属红旗医院博士基金项目(2024-HQBS-12) （2024-HQBS-12）
牡丹江医学院研究生导师科研专项计划(YJSZX2022064) （YJSZX2022064）
牡丹江市应用技术研究与开发计划项目(HT2022NS076) （HT2022NS076）
