北京中医药大学学报2025，Vol.48Issue(7)：889-895,7.DOI:10.3969/j.issn.1006-2157.2025.07.001
基于逍遥散方证科学内涵探讨中医"病-证-方"的研究范式
Exploring the research paradigm of"disease-syndrome-prescription"in traditional Chinese medicine based on the formula-syndrome scientific connotation of Xiaoyao Powder
摘要
Abstract
As the defining characteristic and essence of traditional Chinese medicine(TCM),the integration of disease and syndrome,along with the correlation between syndrome and prescription,forms the foundation for syndrome differentiation and treatment,and guides the clinical diagnosis and treatment practice of TCM.However,key scientific questions remain unresolved regarding the"disease-syndrome-prescription"framework,particularly the biological basis of diseases and syndromes,the active pharmacodynamic constituents of compound formulas,and their mechanism of action.Furthermore,a systematic paradigm for investigating"disease-syndrome-prescription"relationships has not been established,restricting the innovation and development of TCM theory and practice.Xiaoyao Powder,which was first described in a medical book named Taiping Huimin Heji Ju Fang written during the Song Dynasty of China,disperses stagnated liver qi for relieving qi stagnation,thus nourishing the blood and strengthening the spleen,making it a representative prescription for addressing depression due to liver qi stagnation and spleen deficiency under the guidance of correspondence between syndrome and prescription.Therefore,base on the combination of disease and syndrome,and correspondence between syndrome and prescription,investigating the formula-syndrome scientific connotation of Xiaoyao Powder and exploring the research paradigm for the"disease-syndrome-prescription"can provide insights into TCM theory from the perspective of modern science.关键词
病证结合/方证相应/辨证论治/研究范式Key words
integration of disease and syndrome/correlation between syndrome and prescription/syndrome differentiation and treatment/research paradigm分类
医药卫生引用本文复制引用
郝闻致,李晓娟,薛飞飞,陈家旭..基于逍遥散方证科学内涵探讨中医"病-证-方"的研究范式[J].北京中医药大学学报,2025,48(7):889-895,7.基金项目
国家重点研发计划项目(No.2023YFE0209500) （No.2023YFE0209500）
国家自然科学基金项目(No.82405240,No.82430126,No.82074331) （No.82405240,No.82430126,No.82074331）
国家资助博士后研究人员计划(No.GZB20230269) （No.GZB20230269）
第74 批博士后面上项目(No.2023M741396) （No.2023M741396）
中央高校基本科研业务费(No.21624358) （No.21624358）
广东省基础与应用基础研究基金(No.2023A1515110693,No.2025A04J3396) National Key R&D Program of China(No.2023YFE0209500) （No.2023A1515110693,No.2025A04J3396）
