北京中医药大学学报2025，Vol.48Issue(7)：896-902,7.DOI:10.3969/j.issn.1006-2157.2025.07.002
从肝脾同治视角探讨下丘脑-垂体-肾上腺轴与肠脑轴双向调节抑郁症
Bidirectional modulation of depression disorder through the hypothalamic-pituitary-adrenal axis and gut-brain axis from the perspective of simultaneous treatment of the liver and spleen
摘要
Abstract
As a major global public health concern,the incidence of depression disorder is increasing annually.The pathological mechanism of depression involves bidirectional dysregulation between the hypothalamic-pituitary-adrenal(HPA)and gut-brain axes.According to traditional Chinese medicine(TCM),the liver controls conveyance and dispersion,the spleen governs transportation and transformation,and both jointly maintain the balance between ascending and descending qi movement and zang fu viscera function in the body.Liver qi stagnation and spleen deficiency result in qi movement disorder and a lack of source qi and blood,leading to depression induced by malnutrition of heart spirit.As a classic prescription for soothing the liver,invigorating the spleen,and replenishing blood,Xiaoyao Powder is used to reinforce healthy qi and eliminate pathogenic factors.Xiaoyao Powder not only regulates the"yin in property of liver"but also strengthens the"ascending and descending"of the spleen.As commonly used by ancient and modern physicians,also indirectly inhibits HPA axis upregulation and improves depression-related gastrointestinal dysfunction.This paper systematically expounds the multi-dimensional mechanism of Xiaoyao Powder in treating depression through the two-way regulation of the HPA-gut-brain axis.It reveals the therapeutic characteristics of"multi-component and multi-target"in TCM to provide a novel theoretical basis for the modernization of TCM and the treatment of depression by combining TCM and Western medicine.关键词
抑郁症/下丘脑-垂体-肾上腺轴/肠脑轴/肝郁脾虚/逍遥散Key words
depression disorder/hypothalamic-pituitary-adrenal axis/gut-brain axis/stagnation of liver qi and spleen deficiency/Xiaoyao Powder分类
医药卫生引用本文复制引用
南楠,郝闻致,李琳,刘玥芸,陈家旭..从肝脾同治视角探讨下丘脑-垂体-肾上腺轴与肠脑轴双向调节抑郁症[J].北京中医药大学学报,2025,48(7):896-902,7.基金项目
国家自然科学基金项目(No.82430126,No.82174278,No.82405240) National Natural Science Foundation of China(Nos.82430126,82174278,and 82405240) （No.82430126,No.82174278,No.82405240）
