北京中医药大学学报2025，Vol.48Issue(7)：954-959,6.DOI:10.3969/j.issn.1006-2157.2025.07.009
从"肾精-天癸"探讨雷公藤多苷所致儿童生殖毒性的中医药防治思路
Prevention and treatment strategies for reproductive toxicity of Tripterygium wilfordii multiglucoside in children based on the"kidney essence-tian gui"
摘要
Abstract
Tripterygium wilfordii multiglucoside,the primary active constituent of the Chinese materia medica of Tripterygium wilfordii,has anti-inflammatory and immune-regulation properties and is widely used to treat kidney and rheumatic and immunological diseases.However,the potential adverse effects of Tripterygium wilfordii multiglucoside on pediatric gonadal development have limited its clinical application in pediatrics.According to the traditional Chinese medicine theory,the reproductive toxicity of Tripterygium wilfordii is closely associated with deficiency in kidney essence and tian gui disorder.Based on the"kidney essence-tian gui"theory,this study elucidates the transformation of"kidney essence to tian gui"through the qi transformation of"original noumenon to supreme ultimate,"which is synergistically regulated by the accumulation of kidney qi,consolidation of spleen qi,and conveyance and dispersion of liver qi.It is channeled through the interconnected pathways of the thoroughfare channel,conception channel,and governor channel.The physiological process of"kidney essence to tian gui"is damaged by the bitter,cold,and toxicity of Tripterygium wilfordii,leading to kidney asthenia,spleen deficiency,liver depression,and meridian stagnation,causing tian gui dysregulation.Therefore,this study offers traditional Chinese medicine prevention and treatment strategies for pediatric medication safety,including nourishing the kidney essence to replenish the tian gui source,enhancing the middle jiao to strengthen the tian gui guard,regulating liver qi to promote the operation of tian gui,and unblocking the thoroughfare channel,conception channel,and governor channel to ensure the unobstructed pathway of tian gui.关键词
雷公藤/生殖毒性/儿童/肾精/天癸Key words
Tripterygium wilfordii/reproductive toxicity/children/kidney essence/tian gui分类
医药卫生引用本文复制引用
许济祥,张霞,刘嘉贤,包瑞芸,宋纯东,任献青,丁樱..从"肾精-天癸"探讨雷公藤多苷所致儿童生殖毒性的中医药防治思路[J].北京中医药大学学报,2025,48(7):954-959,6.基金项目
国家自然科学基金面上项目(No.82474568) （No.82474568）
中华中医药学会青年求实项目(No.2025-QSDXWT-04) （No.2025-QSDXWT-04）
河南省中青年学科带头人培养项目(豫卫人[2022]26 号) National Natural Science Foundation of China(No.82474568) （豫卫人[2022]26 号）
