北京中医药大学学报2025，Vol.48Issue(7)：960-965,6.DOI:10.3969/j.issn.1006-2157.2025.07.010
从"体脏合痹"理论探讨复发性多软骨炎的中医证治
Traditional Chinese medicine diagnosis and treatment of relapsing polychondritis from the perspective of"combined bi-impediment of body constituents and zang organs"theory
摘要
Abstract
Relapsing polychondritis(RP)is a rare and challenging disease characterized by complex clinical manifestations and multi-system damage,primarily affecting cartilaginous tissues and mucopolysaccharide-rich structures throughout the body.Within the framework of traditional Chinese medicine(TCM),a consensus understanding of RP has not been established.This article is based on the theory of"combined bi-impediment of body constituents and zang organs"and analyzes its relationship with RP.RP can belong to this category,and based on its clinical progression,a staged treatment approach is recommended across three phases:acute,persistent,and remission.Pathogenetically,the acute phase is dominated by pathogenic factors such as wind-heat toxin accumulation,phlegm-stasis heat coagulation,immune dysregulation,and intense inflammatory responses.The persistent phase transitions into a deficiency-excess complex pattern,marked by a latent pathogen struggle between pathogenic factors and healthy qi,forming the fundamental pathogenesis underlying RP recurrence.The remission phase is characterized by lingering pathogen residues coupled with healthy qi deficiency,gradually progressing toward immune homeostasis.Therapeutically,treatment follows the principle of"harmonizing balance between healthy qi and pathogenic qi,"with the five zang organs and bodily constituents as the framework,deficiency and excess as the objective,and the meridians and blood vessels as the unity.During the acute phase,the approach emphasizes eliminating evil and detoxifying,treating the body and zang organs together,and dispersing blood stasis and phlegm.In the sustained phase,treatment focuses on strengthening healthy qi and eliminating evil,modifying treatments according to syndrome manifestations,promoting qi flow,and resolving and eliminating phlegm.In the remission phase,the body and zang organs are strengthened and regulated,and masses are eliminated and collaterals are dredged.Clinical application requires accurate stage differentiation to restore normal physiological body and zang organ functions.A staged treatment strategy based on the theory of"combined bi-impediment of body constituents and zang organs"may offer novel insights into the TCM-based management of RP.关键词
风湿免疫病/体脏合痹/复发性多软骨炎/五体痹/五脏痹Key words
rheumatoid and immune diseases/combined bi-impediment of body constituents and zang organs/relapsing polychondritis/five body constituents bi-impediment/five zang organs bi-impediment分类
医药卫生引用本文复制引用
方创贇,黄筱涵,汪悦..从"体脏合痹"理论探讨复发性多软骨炎的中医证治[J].北京中医药大学学报,2025,48(7):960-965,6.基金项目
国家自然科学基金面上项目(No.82274454) National Natural Science Foundation of China(No.82274454) （No.82274454）
