动物营养学报2025，Vol.37Issue(7)：4209-4219,11.DOI:10.12418/CJAN2025.344
母羊妊娠毒血症的发病机制及其营养调控研究进展
Research Progress on Pathogenesis and Nutritional Regulation of Ewe Pregnancy Toxaemia
摘要
Abstract
Pregnancy toxemia is one of the most critical causes of mortality in ewes carrying multiple fetuses(twins or more)during late gestation.It is a nutritional metabolic disorder characterized by glucose and lipid metabolism dysfunction caused by multiple factors.The hallmark symptoms of this disease include hypoglyce-mia,hyperketonemia and neurological dysfunction.In late gestation,ewes carrying multiple fetuses experience a dramatic increase in fetal energy demands,leading to insufficient glucose supply.This forces the maternal body to excessively mobilize fat reserves,resulting in the overproduction of ketone bodies(such as β-hydroxy-butyrate and aceto-acetate)and subsequent hyperketonemia.The core pathogenesis lies in the imbalance be-tween inadequate maternal nutrient intake(particularly a deficiency in readily fermentable carbohy-drates)and the surge in energy requirements for rapid fetal growth,ultimately causing a negative energy balance in the ma-ternal body.This article systematically analyzed pregnancy toxemia from perspectives including its etiology,di-agnostic methods,pathogenesis,molecular regulatory mechanisms,and nutritional prevention strategies,provi-ding scientific guidance for the prevention and treatment of pregnancy toxemia in practical mutton sheep pro-duction.[Chinese Journal of Animal Nutrition,2025,37(7):4209-4219].关键词
妊娠毒血症/发病机制/过瘤胃葡萄糖/烟酸Key words
pregnancy toxaemia/pathogenesis/rumen-protected glucose/nicotinic acid分类
农业科技引用本文复制引用
王雨薇,臧长江,成志强,张铖..母羊妊娠毒血症的发病机制及其营养调控研究进展[J].动物营养学报,2025,37(7):4209-4219,11.基金项目
自治区"三农"骨干人才培养项目(2023SNGGGCC029) （2023SNGGGCC029）
自治区农区高效肉羊品种选育计划项目(xjnqry-Z-2511) （xjnqry-Z-2511）
