中国耳鼻咽喉头颈外科2025，Vol.32Issue(5)：284-287,4.DOI:10.16066/j.1672-7002.2025.05.003
利用二代基因测序Panel提高甲状腺癌的筛查、诊断和预后评估
Enhancing thyroid tumor screening,diagnosis and prognostic assessment through panel next-generation sequencing
摘要
Abstract
OBJECTIVE To detect mutated genes in thyroid cancer using next-generation sequencing(NGS)Panel and analyze genes associated with the prognosis of thyroid cancer.METHODS Samples from 90 newly diagnosed thyroid cancer patients who underwent surgical treatment at Jilin Cancer Hospital from January 2020 to January 2023 were collected.DNA and RNA were extracted from tissue samples and subjected to high-throughput sequencing.Mutated genes were identified,and their correlation with the patients'AJCC TNM staging and prognosis of thyroid cancer was analyzed.RESULTS Several gene mutations,including FN1,SLC34A2,FABP4,SNCA,MATN2,and EIF2AK1,were detected in thyroid cancer.Among them,FN1 mutation was positively correlated with later stages of the AJCC TNM staging,which is closely associated with prognosis.CONCLUSION FN1 gene mutation may serve as a potential genetic biomarker for predicting the prognosis of thyroid cancer.关键词
甲状腺肿瘤/诊断/预后/二代测序/纤维连接蛋白Key words
Thyroid Neoplasms/Diagnosis/Prognosis/high-throughput nucleotide sequencing/fibronectin引用本文复制引用
孙效松,魏郑超,雒毅强,郑颖,王明..利用二代基因测序Panel提高甲状腺癌的筛查、诊断和预后评估[J].中国耳鼻咽喉头颈外科,2025,32(5):284-287,4.基金项目
吉林省科技发展计划(20210203083SF) （20210203083SF）
