分析化学2025，Vol.53Issue(7)：1127-1137,11.DOI:10.19756/j.issn.0253-3820.251122
基于氮掺杂碳纳米碗修饰电极的电化学传感器用于检测呋喃妥因
Electrochemical Sensor Based on Nitrogen-Doped Carbon Nanobowl-Modified Electrode for Nitrofurantoin Detection
摘要
Abstract
Nitrofurantoin(NFT)is a nitrofuran antibiotic commonly used as a veterinary drug to treat bacterial infections in animals.However,due to the low solubility and bioaccumulation properties,NFT is prone to leave excessive residues in animal-derived foods and water systems,posing serious threats to human health and ecosystems.Therefore,there is an urgent need to develop an efficient and rapid detection method for NFT.In this work,nitrogen-doped carbon nanomaterials with unique bowl-like structures(N-CNBs)were synthesized via a hydrothermal-carbonization method.The morphology,surface structure,and specific surface area of N-CNBs were characterized using transmission electron microscopy(TEM),scanning electron microscopy(SEM),and X-ray photoelectron spectroscopy(XPS).The N-CNB modified glassy carbon electrode(N-CNB/GCE)was prepared,and the electrochemical test revealed that the N-CNB/GCE exhibited higher conductivity and larger electrochemical active surface area compared to bare GCE and nitrogen-doped hollow carbon nanosphere-modified electrode(N-HCNS/GCE).Additionally,the N-CNB/GCE demonstrated superior electrocatalytic activity toward NFT.An NFT electrochemical sensor was constructed based on N-CNB/GCE.The detection conditions of the sensor were optimized,and differential pulse voltammetry(DPV)was employed for NFT detection under optimal experimental conditions.The established NFT electrochemical sensor had a wide linear range of 0.4-500 μmol/L,a low detection limit(S/N=3)of 0.015 μmol/L and high selectivity,with excellent stability and reproducibility.The practical feasibility of this sensor was confirmed by analysis of NFT in milk and tap water samples,with spiked recoveries ranging from 94.2%to 108.9%.关键词
呋喃妥因/氮掺杂碳纳米碗/电化学传感器Key words
Nitrofurantoin/Nitrogen-doped carbon nanobowl/Electrochemical sensor引用本文复制引用
胡耀娟,郭瑞英,唐慧茹,李慧琳,何凤云,张长丽,陈昌云..基于氮掺杂碳纳米碗修饰电极的电化学传感器用于检测呋喃妥因[J].分析化学,2025,53(7):1127-1137,11.基金项目
国家自然科学基金项目(No.22277057)和江苏省自然科学基金项目(No.BK20211013)资助. Supported by the National Natural Science Foundation of China(No.22277057)and the Jiangsu Provincial Natural Science Foundation(No.BK20211013). （No.22277057）
