高等学校化学学报2025，Vol.46Issue(8)：43-53,11.DOI:10.7503/cjcu20250031
氨基烷基萘酚类化合物的合成及抑菌和杀线虫活性
Synthesis of Aminoalkyl Naphthol Analogues and Their Anti-fungal and Nematicidal Activities
摘要
Abstract
A series of amino-alkyl naphthol compounds was synthesized through a one-pot three-component reaction,their antifungal activity against plant pathogenic fungi and nematicidal activity were evaluated.The results showed that compound 8 exhibited about 50%inhibitory activity against Alternaria alternate at concentrations ranging from 200 μg/mL to 25 μg/mL,and the inhibitory effect was not significantly correlated with concentration.In vivo antifungal experiments indicated that compound 8 at a concentration of 50 μg/mL had a therapeutic effect comparable to the positive control pyrimethanil.Additionally,in greenhouse test tube experiments,the synthesized compounds showed significant inhibitory activity against southern root-knot nematodes,with compound 10 significantly reducing the number of galls at a concentration of 10 μg/mL,achieving an inhibition rate of 90.91%,which is comparable to the positive control fluopyram.In summary,amino-alkyl naphthol compounds,as a new type of pesticide active substance,have potential dual effects of antibiosis and nematicide,and the aforementioned research provides new ideas for the development of environmentally friendly multi-target pesticides.关键词
一锅法/氨基烷基萘酚/抗植物病原真菌活性/杀线虫活性Key words
One pot method/Amidoalkyl naphthol/Anti-fungal activity/Nematicidal activity分类
化学化工引用本文复制引用
张琦璘,宋琳,秦玉坤,史衍常,高堃,王林松,宋亚东,王郁森,李鹏程,刘松,邢荣娥..氨基烷基萘酚类化合物的合成及抑菌和杀线虫活性[J].高等学校化学学报,2025,46(8):43-53,11.基金项目
国家自然科学基金(批准号:42076126)、山东省重点研发计划重大科技创新项目(批准号:2022CXGC020413)、青岛市科技惠民示范专项项目(批准号:25-1-5-xdny-7-nsh)、中央引导地方科技发展资金项目(批准号:2024ZY0039)和现代农业产业技术体系专项项目(批准号:CARS-49)资助.Supported by the National Natural Science Foundation of China(No.42076126),the Shandong Key Research and Development Plan,Major Scientific and Technological Innovation Project,China(No.2022CXGC020413),the Qingdao Science and Technology Benefit the People Demon-stration Project,China(No.25-1-5-xdny-7-nsh),the Central Guidance for Local Scientific and Technological Development Funds,China(No.2024ZY0039)and the Special Project on Modern Agricultural Industry Technology System,China(No.CARS-49). （批准号:42076126）
