国际老年医学杂志2025，Vol.46Issue(4)：403-406,4.DOI:10.3969/j.issn.1674-7593.2025.04.004
低剂量乳果糖联合美沙拉嗪对老年溃疡性结肠炎患者炎症水平及临床症状的影响
The impact of low-dose Fructooligosaccharide combined with Mesalazine on inflammation levels and therapeutic effects in elderly patients with ulcerative colitis
摘要
Abstract
Objective To analyze the therapeutic effects,inflammation levels,and safety evaluation of low-dose Fructooli-gosaccharide combined with Mesalazine in elderly patients with ulcerative colitis.Methods Ninety elderly patients with ulcerative co-litis treated in the First teaching Hospital of Xinjiang Medical University from January 2021 to January 2023 were included and random-ly divided into a treatment group and a control group,with 45 patients in each.Both groups received routine treatment upon admission and oral Mesalazine enteric-coated tablets.The treatment group additionally received low-dose Fructooligosaccharide oral solution for 4 weeks.Therapeutic effects,levels of high-sensitivity C reactive protein(hs-CRP),interleukin-8(IL-8),and tumor necrosis factor-α(TNF-α)in serum,and incidence of adverse reactions such as nausea,vomiting,and skin itching were compared.Results The total effective rate in the treatment group was 88.89％(40/45),it was significantly higher than the 64.44％(29/45)in the control group(P＜0.05).There was no significant difference in hs-CRP,IL-8,and TNF-α levels between the two groups before treatment(P＞0.05).After treatment,inflammatory marker levels in the treatment group were significantly lower than those in the control group(P＜0.05).The incidence of adverse reactions was 13.33％in the treatment group and 11.11％in the control group,with no signifi-cant difference between the two groups(P＞0.05).Conclusion Low-dose Fructooligosaccharide combined with Mesalazine can sig-nificantly improve therapeutic effects and reduce inflammation in elderly patients with ulcerative colitis,with a high level of safety.关键词
乳果糖/美沙拉嗪/溃疡性结肠炎/治疗效果/炎症水平Key words
Fructooligosaccharide/Mesalazine/Ulcerative colitis/Therapeutic effects/Inflammation levels引用本文复制引用
王芳芳,姬晓艳,李春花,崔旻..低剂量乳果糖联合美沙拉嗪对老年溃疡性结肠炎患者炎症水平及临床症状的影响[J].国际老年医学杂志,2025,46(4):403-406,4.基金项目
新疆维吾尔自治区自然科学基金项目(2021D01C334) （2021D01C334）
