国际老年医学杂志2025，Vol.46Issue(4)：407-411,5.DOI:10.3969/j.issn.1674-7593.2025.04.005
衰弱在老年2型糖尿病患者社会隔离与认知功能间的中介效应
The mediating effect of frailty between social isolation and cognitive function in elderly patients with type 2 diabetes
摘要
Abstract
Objective To analyze the mediating effect of frailty between social isolation and cognitive function in elderly pa-tients with type 2 diabetes mellitus.Methods A total of 300 elderly patients with type 2 diabetes mellitus admitted to the inpatient de-partment of the Department of Geriatric Endocrinology of the First Affiliated Hospital of Guangxi Medical University from October 2023 to February 2024 were selected by convenience sampling.A general information questionnaire,the Social Network Scale Short Form,the Tilburg Frailty Scale,and the Chinese version of the Simple Intelligent Mental State Examination Scale were used to investigate,and the mediating effect were analyzed using the Process plug-in in SPSS26.0 software.Results 300 elderly patients with type 2 dia-betes mellitus scored 14(9,20)points for social isolation and 103(34.33％)for social isolation;5(3,7)points for frailty and 169(56.33％)for frailty;25(23,27)points for cognitive function and 98(32.67％)for cognitive impairment.The frailty score was neg-atively correlated with the social isolation score(r=-0.327,P＜0.001),the frailty score was negatively correlated with the cognitive function score(r=-0.394,P＜0.001),and the social isolation was positively correlated with the cognitive function score(r=0.370,P＜0.001).Bootstrap test showed that the indirect effect value was 0.071(95％CI:0.038-0.116),indicating that the indirect effect was established;the direct effect was 0.148(95％CI:0.088-0.208),indicating that weakness played a partial mediating role be-tween social isolation and cognitive function,and the indirect effect(0.071)accounted for 32.42％of the total effect(0.219).Conclusion Social isolation,frailty and cognitive impairment in elderly patients with type 2 diabetes type 2 diabetes mellitus are at a high level,and frailty has a partial mediating effect between social isolation and cognitive function in elderly patients with type 2 diabe-tes mellitus,suggesting that social isolation can not only directly affect cognitive function,but also indirectly affect cognitive function through frailty.关键词
2型糖尿病/社会隔离/衰弱/认知功能/中介效应Key words
Type 2 diabetes mellitus/Social isolation/Frailty/Cognitive function/Mediating effect引用本文复制引用
吴妮晓,戴霞,李苏蓝,徐子岚,黄峥..衰弱在老年2型糖尿病患者社会隔离与认知功能间的中介效应[J].国际老年医学杂志,2025,46(4):407-411,5.基金项目
国家自然科学基金资助项目(82160440) （82160440）
