国际老年医学杂志2025，Vol.46Issue(4)：418-423,6.DOI:10.3969/j.issn.1674-7593.2025.04.007
miR-21、TLR4与老年急性冠状动脉综合征患者心室重构和预后的关系
Relationship between miR-21,TLR4 and ventricular remodeling and prognosis in elderly patients with acute coronary syndrome
摘要
Abstract
Objective To investigate the relationship between miR-21,Toll-like receptor 4(TLR4)and ventricular re-modeling and prognosis in elderly patients with acute coronary syndrome(ACS).Methods A total of 100 elderly patients with ACS who received treatment in the People's Hospital of Xinjiang Uygur Autonomous Region from January 2020 to December 2022 were se-lected as the case group,and 100 healthy subjects in the same period were selected as the control group.Serum miR-21 and TLR4 ex-pression and left ventricular remodeling parameters were measured and compared between the two groups,and Pearson correlation was used to analyze the correlation between miR-21 and TLR4 and ventricular remodeling parameters.After 1 year of follow-up,the pa-tients were divided into good prognosis group(66 cases)and poor prognosis group(34 cases)according to whether major adverse car-diovascular events occurred.The serum miR-21 and TLR4 expression levels,ventricular remodeling indicators and related clinical data were compared between poor prognosis group and good prognosis group,and the relationship between miR-21,TLR4 and prognosis was analyzed.Results The levels of miR-21,TLR4,left ventricular mass index(LVMI),mean wall stress(MWS),and relative wall thickness(RWT)in the case group were higher than those in the control group(P＜0.05);Pearson correlation analysis results showed that miR-21 and TLR4 were positively correlated with LVMI,MWS,and RWT(P＜0.05).There were significant differences in age,diabetes,hypertension,and serum miR-21,TLR4,LVMI,MWS,and RWT levels between the good prognosis group and the poor prognosis group(P＜0.05);logistic regression analysis showed that high miR-21 and TLR4 expression,LVMI,MWS,and RWT levels were independent risk factors for poor prognosis in elderly ACS patients(P＜0.05).The ROC curve results showed that the AUCs of miR-21 and TLR4 for predicting poor prognosis in elderly ACS patients were 0.878 and 0.778,respectively,both of which had good predictive efficacy(P＜0.05).Conclusion The expression levels of miR-21 and TLR4 in serum of elderly patients with ACS were significantly increased,which were closely related to ventricular remodeling and prognosis,and had good predictive efficacy for prognosis.关键词
miR-21/Toll样受体4/急性冠状动脉综合征/心室重构/预后Key words
miR-21/Toll-like receptor 4/Acute coronary syndrome/Ventricular remodeling/Prognosis引用本文复制引用
谷佩佩,汪海涛,魏肖慧..miR-21、TLR4与老年急性冠状动脉综合征患者心室重构和预后的关系[J].国际老年医学杂志,2025,46(4):418-423,6.基金项目
新疆维吾尔自治区科技计划项目(2022D01C153) （2022D01C153）
