国际医学放射学杂志2025，Vol.48Issue(4)：415-420,6.DOI:10.19300/j.2025.L22104
超声引导下射频消融治疗邻近被膜甲状腺乳头状癌的疗效分析
Efficacy analysis of ultrasound-guided radiofrequency ablation for papillary thyroid carcinoma adjacent to the thyroid capsule
摘要
Abstract
Objective To investigate the efficacy and safety of ultrasound-guided radiofrequency ablation(US-RFA)in the treatment of papillary thyroid carcinoma(PTC)adjacent to the thyroid capsule.Methods A retrospective analysis was conducted on 126 patients with PTC who underwent US-RFA.Among them,47 cases had PTC adjacent to the thyroid capsule,and 79 cases had non-capsule-adjacent PTC.All patients underwent fine-needle aspiration biopsy(FNAB)before the procedure to confirm pathological diagnosis,and patients with cervical lymph node or distant metastasis were excluded.During the ablation,techniques such as expanded ablation and hydrodissection were applied.Contrast-enhanced ultrasound was performed immediately after the procedure to assess the ablation range and ensure complete ablation.Follow-ups were conducted at 1,3,6,and 12 months postoperatively to monitor changes in the maximum diameter and volume of the ablation site,as well as the occurrence of recurrence,cervical lymph node metastasis,or distant metastasis.Differences between groups were analyzed using t-test,Mann-Whitney U test,and Chi-square test.Results All 126 cases of PTC achieved complete ablation.There were no statistically significant differences in gender,preoperative tumor maximum diameter,preoperative tumor volume,and BRAFV600E between the two groups(all P＞0.05).However,the mean age in the capsule-adjacent group was significantly higher than in the non-capsule-adjacent group(P＜0.05).The rate of hydrodissection use in the capsule-adjacent group(100%)was higher than that in the non-capsule-adjacent group(35.4%).During the follow-up period,there were no significant differencesbetween the two groups in terms of volume reduction rate of the ablation zone and complete tumor disappearance rates at 3 and 12 months postoperatively(all P＞0.05).However,at 6 months after the operation,the complete disappearance rate of the tumor was higher in the non-capsule-adjacent group than in the capsule-adjacent group(P＜0.05).During the follow-up period,no local tumor recurrence or lymph node metastasis was observed in either group.Conclusion US-RFA is a safe and effective treatment for PTC adjacent to the thyroid capsule without lymph node or distant metastasis.关键词
甲状腺乳头状癌/甲状腺被膜/射频消融/超声/疗效分析Key words
Papillary thyroid carcinoma/Thyroid capsule/Radiofrequency ablation/Ultrasound/Efficacy analysis分类
医药卫生引用本文复制引用
李辰晖,张瑞瑞,丁思悦,孙梦锦,牛金灵,李潜..超声引导下射频消融治疗邻近被膜甲状腺乳头状癌的疗效分析[J].国际医学放射学杂志,2025,48(4):415-420,6.基金项目
河南省科技发展计划(222102310194) （222102310194）
