国际神经病学神经外科学杂志2025，Vol.52Issue(3)：10-14,5.DOI:10.16636/j.cnki.jinn.1673-2642.2025.03.002
长程脑室外引流治疗艾滋病合并新型隐球菌性脑膜炎颅高压
Clinical efficacy and safety of long-term external ventricular drainage in treatment of AIDS patients with cryptococcal meningitis and intracranial hypertension
摘要
Abstract
Objective To investigate the clinical efficacy and safety of long-term external ventricular drainage in AIDS patients with cryptococcal meningitis(CM)and intracranial hypertension.Methods A total of 50 AIDS patients with CM and intracranial hypertension who were treated in Shenzhen Third People's Hospital from November 2022 to March 2025 were enrolled as subjects,and they were randomly divided into observation group(long-term external ventricular drainage)and control group(traditional external ventricular drainage),with 25 patients in each group.All patients received standard antifungal and anti-AIDS treatment and intracranial pressure monitoring.The two groups were compared in terms of clinical outcome and complications(intracranial infection,bleeding,and drainage tube leakage).Results There was no significant difference in overall response rate between the observation group and the control group(96.00%vs 80.00%,P>0.05).Compared with the control group,the observation group had a significantly lower incidence rate of complications than the control group(4.00%vs 36.00%,P=0.013),as well as significantly lower incidence rates of intracranial infection,bleeding,and drainage tube leakage.Conclusion Long-term external ventricular drainage has good safety in AIDS patients with CM and intracranial hypertension and can effectively reduce the incidence rate of postoperative complications and the number of surgeries and maintain a normal and stable intracranial pressure,and therefore,it holds promise for clinical application.关键词
长程脑室外引流/艾滋病/新型隐球菌性脑膜炎/颅高压Key words
long-term external ventricular drainage/AIDS/cryptococcal meningitis/intracranial hypertension分类
医药卫生引用本文复制引用
陈思,唐忠,苏丞,张圣坤,张铭芙,李平,赵方,张海涛,初明..长程脑室外引流治疗艾滋病合并新型隐球菌性脑膜炎颅高压[J].国际神经病学神经外科学杂志,2025,52(3):10-14,5.基金项目
深圳市"三名工程"医学团队项目(SZSM202311033) （SZSM202311033）
Sanming Project of Medicine in Shenzhen(SZSM202311033) （SZSM202311033）
深圳市高水平医院建设专项. （）
