国际神经病学神经外科学杂志2025，Vol.52Issue(3)：15-20,6.DOI:10.16636/j.cnki.jinn.1673-2642.2025.03.003
18F-FDG PET/CT和MRI对疑似阿尔茨海默病患者1年内临床进展的评估意义
Significance of 18 F-flurodeoxyglucose positron emission tomography/computed tomography and magnetic resonance imaging in assessing clinical progression within 1 year in patients with suspected Alzheimer disease
摘要
Abstract
Objective To investigate the significance of 18F-flurodeoxyglucose positron emission tomography/computed tomography(18F-FDG PET/CT)and magnetic resonance imaging(MRI)in assessing disease progression within 1 year in amnestic mild cognitive impairment(aMCI)patients suspected of Alzheimer disease(AD).Methods A prospective study was conducted among 146 patients with aMCI,aged 60-90 years,who were treated in Baoding First Central Hospital from August 2021 to August 2022.The outcome of disease progression was recorded within 1 year of follow-up,and the 49 patients with progression to AD were enrolled as progression group,and the 97 patients without progression to AD were enrolled as non-progression group.The methods of 18F-FDG PET/CT and MRI were used to assess disease progression in patients.Results Compared with the non-progression group,the progression group had significantly higher age,content of total tau(T-tau)in cerebrospinal fluid at baseline,and total ventricular volume on MRI(P<0.05),as well as significantly lower Mini-Mental State Examination score and standardized uptake value ratio(SUVR)of the gray matter and white matter on 18F-FDG PET/CT(P<0.05).The univariate and multivariate Logistic regression analyses showed that SUVR and total ventricular volume on MRI were risk factors for disease progression to AD within 1 year of follow-up.SUVR combined with total ventricular volume on MRI had an area under the ROC curve of 0.753(95%confidence interval:0.674-0.832)in predicting disease progression to AD in aMCI patients within 1 year of follow-up,which was better than each predictor used alone.In multivariable models,for every abnormal marker(SUVR<1.063,total ventricular volume on MRI>44 472 mm3 or T-tau>400 ng/L in cerebrospinal fluid)added,the risk of progression to AD graually increased.Conclusions The combination of 18F-FDG PET/CT and MRI has a certain value in predicting disease progression within 1 year in aMCI patients suspected of AD.关键词
阿尔茨海默病/遗忘型轻度认知障碍/18F-氟代脱氧葡萄糖正电子发射断层成像/计算机体层扫描/磁共振成像/疾病进展Key words
Alzheimer disease/amnestic mild cognitive impairment/18F-flurodeoxyglucose positron emission tomography/computed tomography/magnetic resonance imaging/disease progression分类
医药卫生引用本文复制引用
张会朵,齐伟静,耿丽颖,康丽娟..18F-FDG PET/CT和MRI对疑似阿尔茨海默病患者1年内临床进展的评估意义[J].国际神经病学神经外科学杂志,2025,52(3):15-20,6.基金项目
河北省卫健委医学科学研究课题(20241858). （20241858）
