国际神经病学神经外科学杂志2025，Vol.52Issue(3)：21-26,6.DOI:10.16636/j.cnki.jinn.1673-2642.2025.03.004
急性脑梗死患者颅内血管狭窄介入术后谵妄的影响因素分析
Influencing factors for delirium after interventional surgery for intracranial vascular stenosis in patients with acute cerebral infarction
摘要
Abstract
To investigate the influencing factors for delirium after interventional surgery for intracranial vascular stenosis in patients with acute cerebral infarction.Methods A total of 120 patients with acute cerebral infarction who underwent interventional surgery for intracranial vascular stenosis in The Seventh People's Hospital of Zhengzhou from June 2021 to June 2024 were enrolled,and according to the presence or absence of postoperative delirium assessed by the Confusion Assessment Method,the patients were divided into postoperative delirium group with 35 patients and non-postoperative delirium group with 85 patients.The two groups were compared in terms of clinical data,heart rate(HR),mean arterial pressure(MAP),and the serum levels of S-100β protein,neuron-specific enolase(NSE),tumor necrosis factor-α(TNF-α),and interleukin-1β(IL-1β),and the risk factors for postoperative delirium were analyzed.Results Compared with the non-postoperative delirium group,the postoperative delirium group had a significantly higher mean age,a significantly shorter duration of education,and a significantly lower baseline value of regional cerebral oxygen saturation(rScO2)on the surgical side(P<0.05).There were no significant differences in HR and MAP between the two groups at each time point(P>0.05).The postoperative delirium group had significantly higher levels of S-100β protein,NSE,TNF-α,and IL-1β than the non-postoperative delirium group(P<0.05).The multivariate logistic regression analysis showed that age,S-100βprotein,NSE,TNF-α,IL-1β,duration of education,and baseline rScO2 on the surgical side were influencing factors for postoperative delirium(all P<0.05).Conclusions The onset of postoperative delirium is closely associated with age,duration of education,baseline rScO2 on the surgical side,and the serum levels of S-100β protein,NSE,TNF-α,and IL-1β.关键词
急性脑梗死/术后谵妄/颅内血管狭窄介入Key words
acute cerebral infarction/postoperative delirium/intervention surgery for intracranial vascular stenosis分类
医药卫生引用本文复制引用
付记桐,孙光明,王甜甜,代敏,季禾,张本骏,张金苹..急性脑梗死患者颅内血管狭窄介入术后谵妄的影响因素分析[J].国际神经病学神经外科学杂志,2025,52(3):21-26,6.基金项目
河南省医学科技攻关计划项目(LHGJ20220844). （LHGJ20220844）
