国际神经病学神经外科学杂志2025，Vol.52Issue(3)：27-30,4.DOI:10.16636/j.cnki.jinn.1673-2642.2025.03.005
细菌性颅内感染早发性癫痫的影响因素分析
Influencing factors for early-onset epilepsy secondary to bacterial intracranial infection
摘要
Abstract
Objective To investigate the influencing factors for early-onset epilepsy(EE)secondary to bacterial intracranial infection.Methods A retrospective analysis was performed for the clinical data of 213 patients with bacterial intracranial infection who were admitted to Zhongshan Hospital,Xiamen University and The Second Hospital of Longyan from December 2014 to December 2024.According to the presence or absence of EE,the patients were divided into EE group with 23 patients and non-EE group with 190 patients.Results Compared with the non-EE group,the EE group had a significantly higher proportion of patients with a body temperature of≥38.5℃or a Glasgow Coma Scale(GCS)score of≤8 on admission(P<0.05).There were significant differences between the EE group and the non-EE group in serum lactate dehydrogenase,cerebrospinal fluid glucose,and cerebrospinal fluid protein(P<0.05).The univariate Logistic regression analysis showed that a body temperature of≥38.5℃on admission,a GCS score of≤8 on admission,abnormal serum electrolytes,high serum lactate dehydrogenase,low cerebrospinal fluid glucose,and high cerebrospinal fluid protein were associated with secondary EE.The multivariate Logistic regression analysis showed that high serum lactate dehydrogenase,low cerebrospinal fluid glucose,and high cerebrospinal fluid protein were risk factors for secondary EE.Conclusions High serum lactate dehydrogenase,low cerebrospinal fluid glucose,and high cerebrospinal fluid protein are influencing factors for EE secondary to bacterial risk infection.关键词
癫痫/颅内感染/早发性癫痫/细菌Key words
epilepsy/intracranial infection/early-onset epilepsy/bacteria分类
医药卫生引用本文复制引用
罗聪丽,易坤昌,赖有连,郑文富,阳清伟..细菌性颅内感染早发性癫痫的影响因素分析[J].国际神经病学神经外科学杂志,2025,52(3):27-30,4.基金项目
福建省自然科学基金(3502Z20224ZD1038). （3502Z20224ZD1038）
