国际神经病学神经外科学杂志2025，Vol.52Issue(3)：31-36,6.DOI:10.16636/j.cnki.jinn.1673-2642.2025.03.006
基于直立倾斜试验的直立性低血压患者合并帕金森病临床特征研究
Clinical features of patients with orthostatic hypotension comorbid with Parkinson disease:a study based on the head-up tilt test
摘要
Abstract
Objective To investigate the clinical features of patients with orthostatic hypotension(OH)comorbid with Parkinson disease(PD)based on the head-up tilt test(HUTT).Methods A retrospective analysis was performed for 58 patients who attended Nanjing Hospital of Chinese Medicine from May 2019 to December 2024 with the chief complaints of dizziness,unsteady walking,and presyncope and were diagnosed with OH after HUTT,among whom there were 31 patients in the PD group and 27 patients in the non-PD group.Blood pressure was monitored for the patients in both groups during HUTT,and the duration of adherence and changes in blood pressure were observed.Related data including the duration of adherence and blood pressure were compared between the two groups.Results The PD group had a significantly longer disease duration than the non-PD group(P<0.05).The proportion of patients with hypertension was significantly higher in the non-PD group than in the PD group(P<0.05).Compared with the non-PD group,the PD group had a significantly lower completion rate of HUTT(P<0.05),a significantly larger maximum systolic blood pressure difference(P<0.05).The duration of HUTT completion showed no statistically significant difference between the PD and non-PD groups(P>0.05).In the PD group,no significant correlation was found between the maximum systolic blood pressure difference and either disease duration or age(P>0.05).Conclusions Patients with OH comorbid with PD demonstrate poorer HUTT tolerance and more pronounced blood pressure fluctuations than those without PD.HUTT may serve as a valuable tool for assessing autonomic dysfunction in patients with OH comorbid with PD.关键词
帕金森病/直立性低血压/直立倾斜试验/自主神经功能障碍Key words
Parkinson disease/orthostatic hypotension/head-up tilt test/autonomic dysfunction分类
医药卫生引用本文复制引用
崔琪,张家康,俞新浪,刘晓宇,陆艳..基于直立倾斜试验的直立性低血压患者合并帕金森病临床特征研究[J].国际神经病学神经外科学杂志,2025,52(3):31-36,6.基金项目
国家自然科学基金(81804022) （81804022）
南京市中青年拔尖人才项目(宁人才[2020]2号) （宁人才[2020]2号）
2022年全国名老中医药专家传承工作室建设项目[中国中医药人教函[2022]75号] （）
江苏省研究生实践创新计划(SJCX25_1032). （SJCX25_1032）
