国际神经病学神经外科学杂志2025，Vol.52Issue(3)：50-57,8.DOI:10.16636/j.cnki.jinn.1673-2642.2025.03.008
用于神经胶质瘤成像的纳米材料研究进展
Research advances in nanomaterials for glioma imaging
摘要
Abstract
Glioma is one of the most common malignant tumors of the central nervous system,and its diagnosis and treatment have always been a key and difficult issue in medical research.Early diagnosis and accurate imaging are of vital importance for improving the prognosis of patients;however,traditional imaging techniques,such as magnetic resonance imaging,computed tomography,and positron emission tomography,fail to meet the demands of precision medicine due to their limitations in resolution,specificity,and sensitivity.In recent years,the rapid development of nanotechnology has provided new strategies for glioma imaging.Nanomaterials have demonstrated an extremely high biomedical value due to their unique physicochemical properties,including the small size effect,the surface effect,and the quantum size effect.In the field of imaging,nanomaterials can provide a higher resolution and a stronger signal intensity,thereby enabling accurate detection of the tumor microenvironment.Through surface functional modification,nanomaterials can interact with specific molecules in tumor cells or the tumor microenvironment and thus achieve highly specific glioma imaging.While nanomaterials have shown great potential in glioma imaging,there are still great challenges,including the issues of biocompatibility and toxicity and the need to improve targeting and imaging efficiency.Therefore,a systematic review of the research advances in nanomaterials in glioma imaging is important for promoting scientific research,guiding clinical practice,and facilitating the application of new imaging techniques.This article reviews the recent research advances in nanomaterials for glioma imaging,discusses the characteristics,imaging mechanism,and application of different types of nanomaterials,analyzes the main challenges,and looks forward to the future development of the field.关键词
神经胶质瘤/早期诊断/精确成像/纳米材料Key words
glioma/early diagnosis/precise imaging/nanomaterials分类
医药卫生引用本文复制引用
董兴丽,吴佳宁,赵伯言,张程,刘诗雅,靳津,张若天,赵世光..用于神经胶质瘤成像的纳米材料研究进展[J].国际神经病学神经外科学杂志,2025,52(3):50-57,8.基金项目
国家自然科学基金(NO.82272885) （NO.82272885）
深圳市科技计划资助(JCYJ20210324100001004) （JCYJ20210324100001004）
深圳市科技计划资助(JCYJ20230808105205011) （JCYJ20230808105205011）
广东省普通高校重点领域专项项目(2021ZDZX2020). （2021ZDZX2020）
