国际神经病学神经外科学杂志2025，Vol.52Issue(3)：58-65,8.DOI:10.16636/j.cnki.jinn.1673-2642.2025.03.009
目标体温管理在自发性脑出血治疗中的作用
The role of targeted temperature management in treatment of spontaneous intracerebral hemorrhage
龚梦麒 1彭刚 2廖艺玮2
作者信息
- 1. 中南大学湘雅医院,湖南 长沙 410008
- 2. 中南大学湘雅医院,湖南 长沙 410008||国家老年疾病临床医学研究中心(中南大学湘雅医院),湖南 长沙 410008||湖南省脑血管疾病临床医学研究中心(中南大学湘雅医院),湖南 长沙 410008
- 折叠
摘要
Abstract
Spontaneous intracerebral hemorrhage(sICH)remains a huge challenge in clinical medicine due to its high incidence and mortality rates.The pathogenic mechanism of sICH involves the dual influence of primary and secondary brain injuries.Although therapeutic hypothermia has attracted significant attention due to its promising neuroprotective effect in preclinical studies,its efficacy had not been confirmed in clinical trials.Ongoing and upcoming clinical trials aim to elaborate on the impact of targeted temperature management(TTM)in ICH,and recent advances have focused on synergistic therapies combining therapeutic hypothermia with stem cell transplantation and the exploration of individualized TTM regimens.Current challenges lie in how to balance the neuroprotective effect of therapeutic hypothermia against its risks of complications,which may conceal therapeutic benefits.Researchers are trying to optimize the strategies for reducing body temperature,integrate novel technologies for multimodal therapeutic approaches,and conduct high-quality clinical trials,and such efforts are important for unlocking the full therapeutic potential of therapeutic hypothermia.This article reviews the recent studies on TTM and systematically analyzes its basic molecular mechanisms,conceptual evolution,clinical advances,and existing challenges,in order to deepen the understanding and continuously optimize this therapeutic strategy.关键词
自发性脑出血/目标体温管理/低温/继发性脑损伤Key words
spontaneous intracerebral hemorrhage/targeted temperature management/therapeutic hypothermia/secondary brain injury分类
医药卫生引用本文复制引用
龚梦麒,彭刚,廖艺玮..目标体温管理在自发性脑出血治疗中的作用[J].国际神经病学神经外科学杂志,2025,52(3):58-65,8.
