国际神经病学神经外科学杂志2025，Vol.52Issue(3)：73-78,6.DOI:10.16636/j.cnki.jinn.1673-2642.2025.03.011
瞬时受体电位锚蛋白亚型1在偏头痛病理生理机制中的应用
Role of transient receptor potential ankyrin 1 in the pathophysiological mechanisms of migraine
摘要
Abstract
Migraine is a common chronic neurological disorder,and its pathogenesis remains unclear.In recent years,transient receptor potential ankyrin 1(TRPA1)has been the focus in the pathophysiology of various pain disorders including migraine.Genetic and pharmacological data suggest that TRPA1 plays a role in pain sensation and the activation and sensitization of dural afferents.TRPA1-mediated oxidative stress-related migraine triggers may significantly promote the development and progression of migraine and are involved in the pathogenesis of migraine.In addition,TRPA1 channel protein is widely expressed in the trigeminal nervous system and the brain regions closely associated with the pathophysiology of migraine,and furthermore,it is co-localized with the neuropeptides that are associated with the attack and progression of migraine.This article reviews the role of TRPA1 channel in the pathophysiological mechanisms of migraine and their therapeutic applicability,in order to provide new ideas for the treatment of migraine.关键词
偏头痛/瞬时受体电位锚蛋白亚型1/神经源性炎症/氧化应激Key words
migraine/transient receptor potential ankyrin 1/neurogenic inflammation/oxidative stress分类
医药卫生引用本文复制引用
林诗雨,詹逸珺,王瑞奇,裴建..瞬时受体电位锚蛋白亚型1在偏头痛病理生理机制中的应用[J].国际神经病学神经外科学杂志,2025,52(3):73-78,6.基金项目
上海市科学技术委员会科研项目(22Y11922900、18401970500) （22Y11922900、18401970500）
上海市卫生健康委员会海派中医流派传承研究项目[ZY(2021-2023)-0209-10、ZY(2018-2020)-CCCX-1006] （2021-2023）
上海申康重大临床研究项目(SHDC2020CR3091B). （SHDC2020CR3091B）
