国际神经病学神经外科学杂志2025，Vol.52Issue(3)：79-86,8.DOI:10.16636/j.cnki.jinn.1673-2642.2025.03.012
多发性硬化患者灰质损伤的研究进展
Research advances in grey matter injury in patients with multiple sclerosis
摘要
Abstract
Multiple sclerosis(MS)is a demyelinating disease of the central nervous system,with the clinical manifestations of limb weakness,numbness,painful spasms,ataxia,visual impairment,and cognitive impairment(CI).Gray matter(GM)injury in MS has been ignored for a long time.Evidence has shown that GM injury may influence the pathology,neuroimaging manifestations,neuropsychological status,and biomarkers of MS.However,there is limited information on the latest advances in GM injury in MS and potential treatment methods.This article reviews the current understanding of GM injury in MS,including pathology,pathogenesis,clinical features,radiological diagnosis,treatments,and rehabilitation.A more profound understanding of the mechanisms associated with GM injury-related dysfunction can help to develop more effective treatment methods,so as to enhance the overall health of patients with MS.关键词
多发性硬化/灰质损伤/认知障碍Key words
multiple sclerosis/gray matter injury/cognitive impairment分类
医药卫生引用本文复制引用
姚舜禹,文果,彭永,陈全,曾秋明,张镇群..多发性硬化患者灰质损伤的研究进展[J].国际神经病学神经外科学杂志,2025,52(3):79-86,8.基金项目
湖南省卫生健康委员会重点指导课题(C202303076574) （C202303076574）
湖南省中医药管理局重点课题(A2023039) （A2023039）
株洲市科技局课题(2021-009) （2021-009）
湖南中医药高等专科学校附属第一医院优秀科研创新团队(B2021-003) （B2021-003）
2022年湖南中医药大学校院联合基金项目(2022-44). （2022-44）
