神经损伤与功能重建2025，Vol.20Issue(7)：373-377,5.DOI:10.16780/j.cnki.sjssgncj.20230861
亲环素A在糖尿病大鼠血管粥样硬化病变中的作用
The Role of Cyclophilin A in the Development of Vascular Atherosclerotic Lesions in Diabetic Rats
李敏 1孙雪平 1方芳 1魏从兵 1李贺伟2
作者信息
- 1. 中国地质大学(武汉)医院 武汉 430074
- 2. 华中科技大学附属梨园医院 武汉 430070
- 折叠
摘要
Abstract
Objective:To investigate the mechanism by which cyclophilin A(CyPA)promotes the progression of atherosclerosis in diabetic rats.Methods:Thirty male Wistar rats were randomly divided into three groups(n=10 each):the control group,the atherosclerosis group(AS group),and the diabetic atherosclerosis group(DM group).After 16 weeks,blood glucose levels,atherosclerotic indices,and inflammatory cytokines were measured in all three groups.Pathological changes in the abdominal aorta were observed using hematoxylin-eosin(HE)staining.The expression of CyPA,phosphorylated extracellular signal-regulated kinase 1/2(p-ERK1/2),and nuclear factor-kappa B(NF-κB)in the arteries of each group was detected by Western blotting and immunohistochemistry.Results:Over time,the DM group exhibited significant weight loss,elevated blood glucose levels,increased serum inflammatory cytokines,and a markedly higher atherosclerotic index compared to the other groups(all P＜0.05).The protein expression of CyPA,p-ERK1/2,and NF-κB in the vascular walls of the DM group was significantly increased(all P＜0.05).Conclusion:CyPA protein is highly expressed in the vascular walls of diabetic rats with atherosclerotic lesions,suggesting its potential involvement in the formation and progression of diabetic vascular atherosclerosis.关键词
亲环素A/炎性反应/p-ERK1/2/动脉硬化指数/糖尿病Key words
Cyclophilin A/inflammatory response/p-ERK1/2/arteriosclerosis index/diabetes mellitus分类
医药卫生引用本文复制引用
李敏,孙雪平,方芳,魏从兵,李贺伟..亲环素A在糖尿病大鼠血管粥样硬化病变中的作用[J].神经损伤与功能重建,2025,20(7):373-377,5.
