神经损伤与功能重建2025，Vol.20Issue(7)：414-419,6.DOI:10.16780/j.cnki.sjssgncj.20240941
急性脑卒中后颅内中性粒细胞的死亡和清除
Death and Clearance of Intracranial Neutrophils in Acute Ischemic Stroke
摘要
Abstract
Stroke is characterized by high incidence,disability,mortality,recurrence,which poses a heavy burden on individuals and society.Acute ischemic stroke(AIS)is particularly common in clinical practice,and inflammatory response plays a crucial role in its pathological process.After the onset of AIS,neutrophils are the first activated peripheral immune cells to migrate to the ischemic parenchyma.These activated neutrophils exhibit a longer lifespan and trigger persistent inflammation that can lead to blood-brain barrier disruption,cerebral edema,and neurological deficits.Recent studies have found that intracranial neutrophils can undergo several manner of death:NETosis,apoptosis and pyroptosis.Neutrophils can be phagocytosed and cleared by macrophages/microglia.Moreover,they can also leave the local inflammatory tissue through reverse transendothelial migration.Thus,it is of great significance to elucidate the death and clearance mechanism of intracranial neutrophils for improving the prognosis of AIS.关键词
急性脑卒中/中性粒细胞/NETosis/凋亡/胞葬/焦亡/反向跨内皮迁移/细胞死亡Key words
acute ischemic stroke/neutrophils/NETosis/apoptosis/efferocytosis/pyroptosis/reverse transendothelial migration/cell death分类
医药卫生引用本文复制引用
肖青辉,李清灿,叶娇,李志方,靳慧娟..急性脑卒中后颅内中性粒细胞的死亡和清除[J].神经损伤与功能重建,2025,20(7):414-419,6.基金项目
国家自然科学基金面上项目(小胶质细胞通过CIRBP诱导中性粒细胞NETosis在脑缺血再灌注后脑水肿中的作用和机制,No.82171306) （小胶质细胞通过CIRBP诱导中性粒细胞NETosis在脑缺血再灌注后脑水肿中的作用和机制,No.82171306）
