神经损伤与功能重建2025，Vol.20Issue(7)：426-429,434,5.DOI:10.16780/j.cnki.sjssgncj.20240763
基于肠道菌群探究细胞自噬治疗孤独症谱系障碍的研究进展
Research Progress on Exploring Autophagy Therapy for Autism Spectrum Disorder Based on Intestinal Microbiota
摘要
Abstract
Autism spectrum disorder(ASD)is a neurodevelopmental disorder,and its prevalence has increased significantly in recent years.The etiology of ASD involves multiple factors such as genetics,the environment,and neurodevelopment.However,the specific pathogenesis remains unclear,and currently,there are no safe and effective treatment methods.Studies have shown that based on the"microbiota-gut-brain axis"mechanism,regulating the intestinal microbiota and its metabolites can restore the balance of the gut microbiome,thereby modulating the central nervous system to improve ASD symptoms.Autophagy is an essential metabolic system for maintaining cellular and protein homeostasis.It is involved in the genetic and molecular mechanisms of various neurodevelopmental disorders and is also closely related to ASD-related behaviors and disease progression.This paper aims to explore the relationships among intestinal microbiota,autophagy,and ASD,analyze their regulatory roles in ASD,and investigate the possibility of alleviating ASD symptoms by influencing autophagy through the intestinal microbiota,providing new ideas for the treatment of ASD.关键词
孤独症谱系障碍/肠道菌群/细胞自噬/肠脑轴Key words
Autism spectrum disorder/intestinal microbiota/autophagy/gut-brain axis分类
医药卫生引用本文复制引用
伊晨曦,高峰,赵宁侠..基于肠道菌群探究细胞自噬治疗孤独症谱系障碍的研究进展[J].神经损伤与功能重建,2025,20(7):426-429,434,5.基金项目
国家中医药管理局"中西医结合治疗孤独症谱系障碍真实世界临床研究"(No.GZY-KJS-2023-020) （No.GZY-KJS-2023-020）
孤独症重点研究室2023.5 （）
陕西省重点研发计划("孤独症核心症状的神经机制及干预策略研究",No.S2020-YF-ZDCXL-ZDLSF-0249) （"孤独症核心症状的神经机制及干预策略研究",No.S2020-YF-ZDCXL-ZDLSF-0249）
