广西医学2025，Vol.47Issue(6)：791-795,5.DOI:10.11675/j.issn.0253-4304.2025.06.02
可降解封堵器在室间隔缺损治疗中的应用进展
Application progress on degradable occluder in the treatment of ventricular septal defect
摘要
Abstract
In the method of percutaneous interventional therapy,the preferred regimen for ventricular septal defect(VSD)is the use of an occluder.However,most currently available occluders are made of nickel-titanium alloy materials,which remains permanently in the body after implantation.This may lead to complications such as chronic inflammation,arrhythmias,and cardiac perforation.In 2022,the world's first MemoSorb® degradable occluder was approved for clinical use.This device features self-degrading properties—once implanted at the defect site,it gradually breaks down into carbon dioxide,water,and lactic acid,all of which are harmless to the human body.This innovative occluder not only effectively avoids adverse events associated with traditional occluders(including nickel allergy)but also eliminates interference with subsequent interventional therapy,achieving the goal of"implant-free"interventional therapy.However,current degradable occluders have limited visibility via X-ray imaging,requiring reliance on auxiliary imaging systems and the operator's experience for precise positioning.Future improvements such as material engineering enhancements,structural optimization of the device,and standardized procedural protocols could further enhance the safety and therapeutic efficiency of degradable occluders.关键词
室间隔缺损/可降解封堵器/优势/挑战/综述Key words
Ventricular septal defect/Degradable occluder/Advantages/Challenges/Review分类
医药卫生引用本文复制引用
陈成,刘冬立,庞玉生..可降解封堵器在室间隔缺损治疗中的应用进展[J].广西医学,2025,47(6):791-795,5.基金项目
广西西医类别自筹基金资助项目(20210981) （20210981）
广西儿科疾病临床医学研究中心资助项目(桂科AD22035219) （桂科AD22035219）
