广西医学2025，Vol.47Issue(6)：832-835,4.DOI:10.11675/j.issn.0253-4304.2025.06.09
N-乙酰半胱氨酸溶液支气管肺泡灌洗治疗儿童大叶性肺炎的疗效
Efficacy of bronchoalveolar lavage with N-acetylcysteine solution for the treatment of children with lobar pneumonia
摘要
Abstract
Objective To investigate the efficacy of bronchoalveolar lavage with N-acetylcysteine(NAC)solution for the treatment of children with lobar pneumonia.Methods A total of 90 children with lobar pneumonia were enrolled,and they were randomly assigned to control group or observation group,with 45 cases in each group.Routine therapy was given to both groups,based on which normal saline and NAC solution combined with normal saline were given to children for undergoing bronchoalveolar lavage in the control and observation groups,respectively.The two groups were compared in terms of the time required for cough improvement,the time for symmetrical lung breath sounds,the time for wheezing recovery,the time for fever resolution,the duration of antibiotic use,the length of hospital stay,and the time for lung rales to disappear,as well as 2-week post-treatment white blood cell counts,neutrophil percentage,serum C-reactive protein(CRP)level,and clinical efficacy.Results After 2 weeks of treatment,the observation group exhibited shorter time required for cough improvement,time for symmetrical lung breath sounds,time for wheezing recovery,and time for fever resolution compared to the control group(P<0.05).After 2 weeks of treatment,both groups interpreted lower neutrophil percentage and serum CRP level as compared with before treatment,and the aforementioned indices of the observation group were lower than those of the control group(P<0.05).The efficacy of the observation group was superior to that of the control group(P<0.05).No adverse reaction related to treatment in both groups was occurred.Conclusion Bronchoalveolar lavage with NAC solution for the treatment of children with lobar pneumonia can more effectively ameliorate clinical manifestations in children,reduce inflammatory responses,and improve efficacy with a favorable safety.关键词
大叶性肺炎/支气管肺泡灌洗/乙酰半胱氨酸溶液/疗效/儿童Key words
Lobar pneumonia/Bronchoalveolar lavage/N-acetylcysteine solution/Efficacy/Children分类
医药卫生引用本文复制引用
柴英英,付杰..N-乙酰半胱氨酸溶液支气管肺泡灌洗治疗儿童大叶性肺炎的疗效[J].广西医学,2025,47(6):832-835,4.基金项目
亳州市重点研发计划项目(bzzc2022012) （bzzc2022012）
