骨研究（英文版）2025，Vol.13Issue(3)：589-604,16.DOI:10.1038/s41413-024-00399-5
Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus
Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus
Yansi Xian 1Qing Jiang 1Baosheng Guo 1Bin Liu 1Tao Shen 1Lin Yang 2Rui Peng 1Hongdou Shen 3Xueying An 4Yutian Wang 5Yu Ben1
作者信息
- 1. Division of Sports Medicine and Adult Reconstructive Surgery,Department of Orthopedic Surgery,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,321 Zhongshan Road,Nanjing 210008 Jiangsu,PR China||State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,22 Hankou Road,Nanjing 210093 Jiangsu,PR China||Branch of National Clinical Research Center for Orthopedics,Sports Medicine and Rehabilitation,321 Zhongshan Road,Nanjing 210008 Jiangsu,PR China||Medical School of Nanjing University,22 Hankou Road,Nanjing 210093 Jiangsu,PR China
- 2. Division of Sports Medicine and Adult Reconstructive Surgery,Department of Orthopedic Surgery,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,321 Zhongshan Road,Nanjing 210008 Jiangsu,PR China||State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,22 Hankou Road,Nanjing 210093 Jiangsu,PR China||Branch of National Clinical Research Center for Orthopedics,Sports Medicine and Rehabilitation,321 Zhongshan Road,Nanjing 210008 Jiangsu,PR China||Division of Sports Medicine and Adult Reconstructive Surgery,Department of Orthopedic Surgery,Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University,321 Zhongshan Road,Nanjing 210008 Jiangsu,PR China
- 3. Division of Sports Medicine and Adult Reconstructive Surgery,Department of Orthopedic Surgery,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,321 Zhongshan Road,Nanjing 210008 Jiangsu,PR China||Medical School of Nanjing University,22 Hankou Road,Nanjing 210093 Jiangsu,PR China
- 4. Division of Sports Medicine and Adult Reconstructive Surgery,Department of Orthopedic Surgery,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,321 Zhongshan Road,Nanjing 210008 Jiangsu,PR China||State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,22 Hankou Road,Nanjing 210093 Jiangsu,PR China||Branch of National Clinical Research Center for Orthopedics,Sports Medicine and Rehabilitation,321 Zhongshan Road,Nanjing 210008 Jiangsu,PR China
- 5. Division of Sports Medicine and Adult Reconstructive Surgery,Department of Orthopedic Surgery,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,321 Zhongshan Road,Nanjing 210008 Jiangsu,PR China
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Yansi Xian,Qing Jiang,Baosheng Guo,Bin Liu,Tao Shen,Lin Yang,Rui Peng,Hongdou Shen,Xueying An,Yutian Wang,Yu Ben..Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus[J].骨研究（英文版）,2025,13(3):589-604,16.基金项目
This work was supported by the National Key Research and Development Project(2021YFA1201404),National Natural Science Foundation of China Major Project(81991514)and General Project(82272530,82372459),Jiangsu Province Medical Innovation Center of Orthopedic Surgery(CXZX202214),Jiangsu Provincial Key Medical Center Foundation,Jiangsu Provincial Medical Outstanding Talent Foundation,Jiangsu Provincial Medical Youth Talent Foundation and Jiangsu Provincial Key Medical Talent Foundation,the Fundamental Research Funds for the Central Universities(14380493,14380494).Schemes were created with BioRender.com.The authors also acknowledge Dr.Yi Chen for her support in completing the cellular Seahorse Assay. （2021YFA1201404）
