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Bone marrow adipogenic lineage precursors are the major regulator of bone resorption in adult mice

Jiawei Lu Yuewei Lin Shovik Bandyopadhyay Kai Tan Yongwen Choi X.Sherry Liu Ling Qin Qi He Huan Wang Lutian Yao Michael Duffy Hanli Guo Corben Braun Yilu Zhou Qiushi Liang

骨研究（英文版）2025，Vol.13Issue(3)：605-617,13.

骨研究（英文版）2025，Vol.13Issue(3)：605-617,13.DOI:10.1038/s41413-025-00405-4

Bone marrow adipogenic lineage precursors are the major regulator of bone resorption in adult mice

Jiawei Lu ¹Yuewei Lin ²Shovik Bandyopadhyay ³Kai Tan ³Yongwen Choi ⁴X.Sherry Liu ²Ling Qin ²Qi He ²Huan Wang ²Lutian Yao ²Michael Duffy ²Hanli Guo ²Corben Braun ²Yilu Zhou ²Qiushi Liang²

作者信息

1. Department of Orthopaedic Surgery,Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA 19104,USA||Department of Spine Surgery,Shanghai East Hospital,School of Medicine,Tongji University,Shanghai 200092,China
2. Department of Orthopaedic Surgery,Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA 19104,USA
3. Department of Pediatrics,Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA 19104,USA||Center for Childhood Cancer Research,The Children's Hospital of Philadelphia,Philadelphia,PA 19104,USA
4. Department of Pathology and Laboratory Medicine,Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA 19104,USA
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摘要

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Jiawei Lu,Yuewei Lin,Shovik Bandyopadhyay,Kai Tan,Yongwen Choi,X.Sherry Liu,Ling Qin,Qi He,Huan Wang,Lutian Yao,Michael Duffy,Hanli Guo,Corben Braun,Yilu Zhou,Qiushi Liang..Bone marrow adipogenic lineage precursors are the major regulator of bone resorption in adult mice[J].骨研究（英文版）,2025,13(3):605-617,13.

基金项目

We thank MicroCT Imaging Core at Penn Center for Musculoskeletal Disorders(PCMD)for their assistance with microCT analysis.We also thank Dr.Jesse Williams at University of Minnesota for his assistance with bone marrow and peripheral blood analysis.This study was supported by NIH grants NIH/NIA R01AG069401(to L.Q.),NIH/NHLBI U54HL165442(to K.T.),and P30AR069619(to Penn Center for Musculoskeletal Disorders). （PCMD）

骨研究（英文版）

ISSN：2095-4700

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