工业微生物2025，Vol.55Issue(3)：7-9,3.DOI:10.3969/j.issn.1001-6678.2025.03.003
乳酸菌作为功能分子给药载体的基因工程研究进展
Progress of Genetic Engineering Research on Lactic Acid Bacteria as Functional Molecular-based Drug Delivery Carriers
摘要
Abstract
There have been more and more evidence supporting the use of lactic acid bacteria(LAB),especially Lactococcus and Lactobacillus strains,as active drug delivery carriers to promote human health..As Gram-positive bacteria,LAB have been used in the production of fermented foods for thousands of years.Numerous studies have shown that lactic acid bacteria can induce systemic and mucosal immune responses against certain antigens during mucosal administration.Therefore,LAB have great potential in developing new mucosal routes of administration.This article mainly reviews the progress of genetic engineering research on LAB as an active carrier of functional molecular-based drug delivery.关键词
乳酸菌/乳酸乳球菌/乳酸杆菌/黏膜给药/活载体Key words
lactic acid bacteria/Lactococcus/Lactobacillus/mucosal administration/active carrier引用本文复制引用
毛瑞峰,陈营营..乳酸菌作为功能分子给药载体的基因工程研究进展[J].工业微生物,2025,55(3):7-9,3.基金项目
国家自然科学基金(编号:81803418) （编号:81803418）
江苏省高等学校自然科学研究面上项目(编号:18KJD350001). （编号:18KJD350001）
