广州医药2025，Vol.56Issue(6)：723-734,745,13.DOI:10.20223/j.cnki.1000-8535.2025.06.001
焦虑症与抑制性神经元功能:小清蛋白神经元的作用
The role of parvalbumin positive inhibitory neurons in anxiety disorders
摘要
Abstract
Anxiety disorders,distinct from physiological anxiety,are characterized by a chronic and pervasive state of heightened anxiety and represent the most common mental diseases.Emerging evidence implicates inhibitory neurons in both the generation and extinction of physiological anxiety,with dysfunction in these neurons strongly associated with the pathogenesis of anxiety disorders.Among inhibitory neurons,parvalbumin(PV)-positive interneuron,a key subset with unique morphological and functional characteristics,are widely distributed across the cerebral cortex and various brain regions.These neurons exert rapid,potent inhibitory control over local microcircuits and broader neural networks through their fast-spiking activity,making them integral to the regulation of anxiety-related behaviors.This review highlights three key aspects:the anatomical and functional properties of PV neurons;their role in circuit mechanisms;the molecular pathways by which PV neurons regulate anxiety.By elucidating the role of PV neurons in modulating physiological anxiety and highlighting their dysfunction in anxiety disorders,this review aims to inform future research and foster the development of novel therapeutic interventions for anxiety disorders.关键词
小清蛋白神经元/抑制性神经元/焦虑症Key words
parvalbumin neurons/inhibitory neurons/anxiety disorders引用本文复制引用
华丽博,方长荣,陈俊良,赵铮,刘勇,黄浪..焦虑症与抑制性神经元功能:小清蛋白神经元的作用[J].广州医药,2025,56(6):723-734,745,13.基金项目
国家自然科学基金(82071188,32300840) （82071188,32300840）
科技创新2030(2022ZD0214300) （2022ZD0214300）
广州市科技计划项目(2024A04J4004) （2024A04J4004）
