广州医药2025，Vol.56Issue(6)：760-765,6.DOI:10.20223/j.cnki.1000-8535.2025.06.005
免疫联合化疗对晚期NSCLC患者淋巴细胞免疫及生活质量的影响
Effect of immunotherapy combined with chemotherapy on lymphocyte immunity and quality of life in patients with advanced NSCLC
摘要
Abstract
Objective To explore the effect of immunotherapy combined with chemotherapy on lymphatic immunity and quality of life of patients with advanced non-small cell lung cancer(NSCLC),and to provide reference for further clinical treatment.Methods A total of 120 patients with NSCLC from June 2021 to June 2023 were selected and divided into observation group and control group evenly according to the method of drawing lots,control group was treated with chemotherapy,the observation group was treated with immunotherapy combined with chemotherapy,and the clinical efficacy and adverse drug reactions were compared between the two groups.Before and after treatment,immune function(CD3+,CD4+,CD8+),carbohydrate antigen 199(CA199),carbohydrate antigen 125(CA125),serum carcinoembryonic antigen(CEA)levels and health status questionnaire(QOL-RRB-scores)were measured.Results The total effective rate in the observation group was significantly higher than that in the control group(68.33%＞41.67%,P＜0.05).After treatment,the ratios of CD3+and CD4+in the observation group were significantly higher than those before treatment and control group after treatment,and the ratio of CD8+was significantly lower than that before and after treatment in the control group(P＜0.05).After treatment,the serum levels of CA199,CA125 and CEA in the observation group were lower than those before and after treatment in the control group(P＜0.05).The incidence of adverse drug reactions was 16.67%in the observation group and 36.67%in the control group,which was significantly lower in the observation group than in the control group(P＜0.05).After treatment,the QOL scores in the observation group were significantly higher than those in the control group and before treatment(P＜0.05).Conclusions Compared with chemotherapy alone,immunotherapy combined with chemotherapy can effectively reduce the levels of tumor markers,improve the immune indexes of patients,reduce the adverse drug reactions,and improve the efficacy and quality of life of patients with advanced NSCLC.关键词
非小细胞肺癌/化疗/免疫/生活质量Key words
non-small-cell lung cancer/chemotherapy/immunity/quality of life引用本文复制引用
武变荣,骆玉霜..免疫联合化疗对晚期NSCLC患者淋巴细胞免疫及生活质量的影响[J].广州医药,2025,56(6):760-765,6.基金项目
青海省科技厅科技项目(2022-ZJ-744) （2022-ZJ-744）
