广州医药2025，Vol.56Issue(6)：766-774,9.DOI:10.20223/j.cnki.1000-8535.2025.06.006
基于生物信息学分析TRIB2与结肠癌预后和免疫浸润相关性
Correlation of TRIB2 expression with prognosis and immune infiltration in colon cancer based on bioinformatics
摘要
Abstract
Objective To explore the expression of TRIB2 in colon cancer and its relationship with prognosis and immune cell infiltration.Methods TIMER database was used to analyse the expression of TRIB2 in pan-cancer.RNA-seq data and clinical information of colon cancer patients were downloaded from TCGA and GSE17538 to assess the correlation between TRIB2 with clinicopathological features.Survival curves,univariate and multivariate COX regression analysis were performed to explore the correlation between TRIB2 and prognosis,and a nomogram was constructed.Gene enrichment analyses were performed for TRIB2.Correlations between TRIB2 expression and immune cell infiltration,immune checkpoints,tumor mutation burden(TMB),and immunotherapy sensitivity were analyzed.Results TRIB2 was highly expressed in colon cancer tissues(P＜0.05).The highest level of TRIB2 mRNA expression was found in CMS1.TRIB2 was an independent prognostic factor for colon cancer patients(univariate Cox regression analysis:HR=1.397,95%CI:1.100-1.774,P=0.006;multivariate Cox regression analysis:HR=1.502,95%CI:1.158-1.947,P=0.002).TRIB2 was closely associated with immune cell infiltration and positively correlated with the expression level of immune checkpoint molecules as well as TMB(r=0.39,P＜0.001).The expression of TRIB2 was correlated with the efficacy of immune checkpoint inhibitors.Conclusions TRIB2 is highly expressed in colon cancer and is closely associated with poor prognosis and the immune microenvironment of colon cancer patients.关键词
结肠癌/TRIB2/预后/免疫Key words
colon cancer/TRIB2/prognosis/immunity引用本文复制引用
万璐颖,李静宜,谢贤和..基于生物信息学分析TRIB2与结肠癌预后和免疫浸润相关性[J].广州医药,2025,56(6):766-774,9.基金项目
福建省教育厅中青年教师教育科研项目(JAT210092) （JAT210092）
