海南医科大学学报2025，Vol.31Issue(13)：1022-1031,10.DOI:10.13210/j.cnki.jhmu.20250417.002
不同视角下探讨溃疡性结肠炎最新发病机制的研究进展
Exploring the latest pathogenesis of ulcerative colitis from different perspectives
摘要
Abstract
Ulcerative colitis(UC)is a chronic and non-specific intestinal inflammatory disease,characterized by the continu-ous and diffuse inflammatory changes of the rectal mucosa.In recent years,with the change of people's life style and various life factors,the incidence of UC has gradually increased worldwide,and the peak age of incidence groups shows a trend of younger age.The pathogenesis of UC is complex and not fully defined,but it is closely related to genetic factors,environmental factors,in-testinal flora dysregulation,immune system disorders,abnormal signal pathway conduction and other factors.The interaction of these factors may lead to continuous inflammation of intestinal mucosa,thus causing a series of symptoms of UC.Although a large number of studies have explored the role of genetic,environment,intestinal flora,immune system disorders and signaling pathway abnormalities in UC,they mostly focus on the independent influence of a single factor and lack a systematic analysis of multifactor interaction.From an innovative multi-dimensional perspective,this paper integrates for the first time the interaction of genetic sus-ceptibility genes,dynamic balance of intestinal flora,abnormal activation of signaling pathway and the immune system,and re-veals the mechanism of how these factors act together to lead to persistent inflammation of intestinal mucosa.This systematic anal-ysis of multifactorial interaction not only provides new perspectives on the etiological mechanism of UC,but also brings new hope for the development of personalized treatment programs and improving the quality of life of patients.关键词
溃疡性结肠炎/肠道菌群/基因编辑/多因素交互作用/信号通路Key words
Ulcerative colitis/Intestinal microbiota/Gene editing/Multifactorial interaction effects/Signal channel分类
医药卫生引用本文复制引用
李晨,周可丽,支芸芸,黄雪青,梅蒙玉,牛海艳,任守忠..不同视角下探讨溃疡性结肠炎最新发病机制的研究进展[J].海南医科大学学报,2025,31(13):1022-1031,10.基金项目
This study was supported by the Hainan Provincial Health Science and Technology Innovation Joint General Project(WSJK2025MS184) 海南省卫生健康科技创新联合面上项目(WSJK2025MS184) （WSJK2025MS184）
