天然产物调控免疫细胞参与肿瘤免疫逃逸的作用机制研究进展
Research progress on the mechanism of natural products regulating immune cells involved in tumor immune escape
摘要
Abstract
Immune escape is a key factor leading to tumor metastasis and recurrence.At present,immunotherapy has gradual-ly become a new way of cancer treatment and has achieved remarkable results in clinical treatment.Natural products are an impor-tant source of drug development,showing a variety of biological activities and great potential in cancer immunotherapy.A large number of studies have found that natural products can indirectly regulate the activity of immune cells in a variety of cancer types by directly regulating innate immune cells and adaptive immune cells,or by regulating related cytokines and signaling pathways,so as to reshape the tumor microenvironment,enhance the immune surveillance ability of the immune system,and then inhibit the tumor immune escape process.Therefore,the mechanism of natural products participating in tumor immune escape by regulating immune cells is reviewed in order to provide medication guidance and ideas for the development of new strategies for tumor immunotherapy.关键词
天然产物/免疫细胞/肿瘤免疫逃逸Key words
Natural products/Immune cells/Tumor immune escape分类
医药卫生引用本文复制引用
谢瑛莹,李东东,张晓青,马纯政,胡亦杨,赵宁宁,张娟..天然产物调控免疫细胞参与肿瘤免疫逃逸的作用机制研究进展[J].海南医科大学学报,2025,31(13):1032-1040,9.基金项目
This study was supported by National Natural Science Foundation of China(82204981) （82204981）
Traditional Chinese Medicine Discipline Construction Project of Henan Province(STG-ZYX06-202145) （STG-ZYX06-202145）
Special Project for Scientific Research of Traditional Chinese Medicine in Henan Province(2021JDZX2002) （2021JDZX2002）
Doctoral Research Fund of Henan Provincial Hospital of Traditional Chinese Medicine(2022BSJJ07) （2022BSJJ07）
Doctoral Research Fund of Henan Provincial Hospital of Traditional Chinese Medicine(2023BSJJ02) （2023BSJJ02）
Special Project for Scientific Research of Traditional Chinese Medicine in Henan Province(20-21ZY2115) （20-21ZY2115）
2022 Graduate Research and Innovation Capability Enhancement Plan Project of Henan University of Traditional Chinese Medicine(2022KYCX057) （2022KYCX057）
2023 Graduate Research and Innovation Capability Enhancement Plan Project of Henan University of Traditional Chinese Medicine(2023KYCX043) （2023KYCX043）
2023 Graduate Research and Innovation Capability Enhancement Plan Project of Henan University of Traditional Chinese Medicine(2023KYCX051) 国家自然科学基金资助项目(82204981) （2023KYCX051）
河南省特色骨干学科中医学学科建设项目(STG-ZYX06-202145) （STG-ZYX06-202145）
河南省中医药科学研究专项课题(2021JDZX2002) （2021JDZX2002）
河南省中医院博士科研基金(2022BSJJ07) （2022BSJJ07）
河南省中医院博士科研基金(2023BSJJ02) （2023BSJJ02）
河南省中医药科学研究专项课题(20-21ZY2115) （20-21ZY2115）
河南中医药大学2022年度研究生科研创新能力提升计划项目(2022KYCX057) （2022KYCX057）
河南中医药大学2023年度研究生科研创新能力提升计划项目(2023KYCX043) （2023KYCX043）
河南中医药大学2023年度研究生科研创新能力提升计划项目(2023KYCX051) （2023KYCX051）
