海南医科大学学报2025，Vol.31Issue(14)：1095-1102,8.DOI:10.13210/j.cnki.jhmu.20240927.002
GSDMD高表达与脑胶质瘤患者预后不良的相关性研究
Correlation between high expression of GSDMD and poor prognosis in patients with glioma
摘要
Abstract
Objective:To investigate the expression of the pyroptosis execution protein GSDMD in glioma and its correlation with patient prognosis.Methods:This study analyzed glioma and normal brain tissue samples from the TCGA and CGGA databas-es using bioinformatics methods to statistically evaluate differences in Gasdermin gene expression.Immunohistochemistry was used to verify the expression levels of GSDMD protein in clinical glioma samples.Kaplan-Meier survival analysis and multivariate Cox regression models were employed to assess the relationship between GSDMD expression and patient prognosis.Results:GS-DMD expression in glioma tissues was significantly higher than in normal brain tissues.Survival analysis indicated that the overall survival time of the high GSDMD expression group was significantly shorter than that of the low expression group.Additionally,high GSDMD expression was associated with higher-grade gliomas and higher Ki-67 labeling index.Conclusion:The study results suggest that GSDMD expression levels are closely related to the prognosis of glioma patients,and GSDMD can serve as an inde-pendent indicator of poor prognosis.Detection of GSDMD may aid in the prognosis assessment and individualized treatment strate-gy development for glioma patients.关键词
脑胶质瘤/GSDMD/细胞焦亡/生物标志物/预后Key words
Glioma/GSDMD/Pyroptosis/Biomarker/Prognosis分类
医药卫生引用本文复制引用
杨操,葛畅,徐敬轩..GSDMD高表达与脑胶质瘤患者预后不良的相关性研究[J].海南医科大学学报,2025,31(14):1095-1102,8.基金项目
This study was supported by the Open Project of State Key Laboratory of Causes and Prevention of High Morbidity in Central Asia jointly established by the Ministry and Provincial Government of China(SKL-HIDCA-2022-NKX5) 省部共建中亚高发病成因与防治国家重点实验室开放课题项目(SKL-HIDCA-2022-NKX5) （SKL-HIDCA-2022-NKX5）
