华侨大学学报（自然科学版）2025，Vol.46Issue(4)：369-378,10.DOI:10.11830/ISSN.1000-5013.202504010
参与肺癌靶向耐药的lncRNAs的作用及其机制
Role of LncRNAs in Targeted Drug Resistance in Lung Cancer and Their Mechanisms
摘要
Abstract
The roles and mechanisms of long non-coding RNAs(lncRNAs)involved in targeted drug resist-ance in lung cancer were analyzed comprehensively,elucidating multiple biomarkers for treating lung cancer re-sistance.By reviewing relevant literature in recent years,the involvement in cisplatin(DDP)resistance in lung cancer,targeted epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs)resistance,targeted anaplastic lymphoma kinase tyrosine kinase inhibitors(ALK-TKIs)resistance,and various long non-coding RNAs(lncRNAs)resistant to immunotherapy were summarized,and its role and contribution in reversing drug resistance in lung cancer were analyzed.The results show that among the lncRNAs associated with EGFR-TKIs targeted resistance,LINC00460 not only regulates gefitinib resistance through activation of the miR-338-3p/SMC4 pathway,but also plays a crucial role in resistance to osimertinib.Additionally,lung ade-nocarcinoma metastasis-associated transcript 1 has been shown to affect immune resistance by modulating the expression of major histocompatibility complex proteins and programmed death-ligand 1,highlighting its po-tential as a key therapeutic target for improving the outcomes of immunotherapy in lung cancer.关键词
长链非编码RNAs(lncRNAs)/肺癌/顺铂耐药/靶向耐药/分子机制Key words
long non-coding RNAs(lncRNAs)/lung cancer/cisplatin resistance/targeted drug resistance/molecular mechanism分类
医药卫生引用本文复制引用
杨素心,马丽浩,张景红..参与肺癌靶向耐药的lncRNAs的作用及其机制[J].华侨大学学报（自然科学版）,2025,46(4):369-378,10.基金项目
福建省科技计划引导性项目(2018Y0062) （2018Y0062）
福建省厦门市自然科学基金面上资助项目(3502Z202373044) （3502Z202373044）
