基础医学与临床2025，Vol.45Issue(8)：982-991,10.DOI:10.16352/j.issn.1001-6325.2025.08.0982
基于质谱的尿液蛋白质组的临床应用
Clinical applications of urine proteome based on mass spectrometry
摘要
Abstract
Urine is stable,non-invasive obtaining and has simple composition.As urine is not regulated by homeo-static mechanisms,it is easier to detect early changes of disease comparing with blood,making urine as an ideal bi-omarker source.In recent years,with the improvement of mass spectrometry technology and detection throughput,research in the field of clinical urine proteomics has made significant progress.Urine can not only reflect the func-tional changes of the disease at the tissue level,but also provide a new path for monitoring the efficacy of individu-alized medication.This review systematically summarizes the research progress of urine proteomics in the diagnosis of non-urinary system diseases in the past decade(2015-2024).This review also discusses the application of urine proteomics in disease monitoring,prognosis evaluation,drug efficacy assesment,and traditional Chinese med-icine.Finally,future development prospects of urine proteomics are discussed.关键词
尿蛋白组学/生物标志物/早期诊断/临床应用Key words
urine proteomics/biomarkers/early diagnosis/clinical application分类
医药卫生引用本文复制引用
魏静,孙伟..基于质谱的尿液蛋白质组的临床应用[J].基础医学与临床,2025,45(8):982-991,10.基金项目
北京市自然科学基金-大兴创新联合基金重点研究专题项目(L246002) （L246002）
