基础医学与临床2025，Vol.45Issue(8)：999-1009,11.DOI:10.16352/j.issn.1001-6325.2025.08.0999
尿液代谢组学研究技术进展及其在癌症诊断中的应用
Progress in urinary metabolomics research technologies and applications in cancer diagnosis
陈凌云 1陈文嵩 2孙勤强 2訾金2
作者信息
- 1. 深圳华大生命科学研究院,广东 深圳 518083
- 2. 深圳华大基因科技服务有限公司,广东 深圳 518083
- 折叠
摘要
Abstract
Urine metabolomics serves as a crucial approach for discovering non-invasive biomarkers.It enables the detection of metabolite variations during disease progression and therapeutic interventions,offering novel insights for early disease diagnosis,prevention,and personalized treatment.Compared to other bodily fluids,urine exhibits dis-tinctive advantages,including ease of collection,metabolite abundance,and the capacity to promptly reflect bio-chemical metabolic pathway alterations in vivo.Strict adherence to standardized protocols for sample collection and preservation is imperative in urine metabolomics research.Nuclear magnetic resonance(NMR)and mass spectrom-etry(MS)are primary analytical techniques in urine metabolomics studies.Given the complex composition of urina-ry metabolites,appropriate analytical technologies should be selected based on specific research objectives,the combination of multiple techniques often employed to enhance the comprehensiveness and accuracy of metabolite analysis in samples.This review focuses on major technological advancements in urine metabolomics and their appli-cations in biomarker discovery from cancer screening.关键词
尿液代谢组学/核磁共振/质谱/癌症诊断Key words
urinary metabolomics/nuclear magnetic resonance/mass spectrometry/cancer diagnosis分类
生物科学引用本文复制引用
陈凌云,陈文嵩,孙勤强,訾金..尿液代谢组学研究技术进展及其在癌症诊断中的应用[J].基础医学与临床,2025,45(8):999-1009,11.
