基础医学与临床2025，Vol.45Issue(8)：1034-1040,7.DOI:10.16352/j.issn.1001-6325.2025.08.1034
大鼠体质量和体长对颈总动脉球囊拉伤致血管狭窄模型的影响
Effect of body weight and length on carotid artery vascular stenosis induced by balloon strain in rats
摘要
Abstract
Objective To investigate the effects of body weight and length of SD rats on the carotid artery balloon injury-induced vascular stenosis model in order to provide a reference for replicating an ideal vascular stenosis mod-el.Methods Male rats were divided into three groups based on body weight and length.The CONQUEROR™ SC PTCA balloon catheter was employed,with a fixed balloon inflation volume of 0.2 mL to induce injury in the left common carotid artery,while the right side served as a control.As soon as surgery operation,one rat from each group was selected for Evans Blue dye verification.Fourteen days later,the injured and contra lateral common ca-rotid arteries from remaining rats were harvested for HE staining to check the extent of stenosis.Based on these find-ings,six rats within the optimal range of body weight and length were selected for further validation.Results Rats with body weights ranging from 280 to 380 g(corresponding body lengths of 21.0-26.5 cm)underwent balloon catheter injury,resulting in endothelial detachment and varying degrees of stenosis in the common carotid artery.In rats weighing 280-300 g(body lengths of 21.0-22.5 cm)had severe stenosis or occlusion of the common carotid artery with thrombosis.In rats weighing 320-340 g(body lengths of 23.0-24.5 cm),the internal and external elastic plates of the common carotid artery were ruptured and the vascular morphology was abnormal.Conversely,rats weighing 360-380 g(body lengths of 25.0-26.5 cm)did not show any ruptured elastic laminae or thrombus formation in the common carotid artery,and the extent of vascular stenos in rats with a body weight of 360 g was moderate and uniform.The results of the repeated validation experiments were consistent.Conclusions Rats with a body weight range of 360 g(corresponding body length of 25.0-26.5 cm)are suitable for development of an ideal vascular stenosis model.关键词
再狭窄/血管成形术/球囊导管/大鼠Key words
restenosis/angioplasty/balloon catheter/rat分类
医药卫生引用本文复制引用
陈天旺,罗加伟,袁乙丹,杨依敏,黄波,徐尚福,李利生..大鼠体质量和体长对颈总动脉球囊拉伤致血管狭窄模型的影响[J].基础医学与临床,2025,45(8):1034-1040,7.基金项目
贵州省科技计划项目(黔科合基础-ZK[2023]一般500) （黔科合基础-ZK[2023]一般500）
