解放军医学杂志2025，Vol.50Issue(6)：665-671,7.DOI:10.11855/j.issn.0577-7402.1474.2025.0327
NF-κB信号通路在胰腺癌耐药机制中的研究进展
Research progress on the role of NF-κB signaling pathway in drug resistance mechanisms of pancreatic cancer
摘要
Abstract
Pancreatic cancer is characterized by significant drug resistance,and despite continuous advancements in treatment regimens,the 5-year survival rate of patients remains low.The nuclear factor-κB(NF-κB)signaling pathway,frequently mutated in tumors,has been identified as a critical factor in triggering drug resistance.Multiple studies have demonstrated that strategies targeting NF-κB signaling transduction exhibit promising outcomes in pancreatic cancer treatment.Therefore,exploring the relationship between the NF-κB signaling pathway and drug resistance in pancreatic cancer has become a research hotspot in pancreatic cancer treatment.This review summarizes recent advances in the relationship between NF-κB signaling pathway and tumor drug resistance,as well as its role in pancreatic cancer treatment.Specifically,the mechanisms by which the NF-κB signaling pathway mediates drug resistance in pancreatic cancer are elaborated from two perspectives:chemotherapy and immunotherapy,aiming to provide insights for pancreatic cancer treatment and future research.关键词
胰腺癌/核因子κB/耐药性/化学治疗/免疫治疗Key words
pancreatic cancer/nuclear factor-κB/resistance/chemotherapy/immunotherapy分类
医药卫生引用本文复制引用
束雅婷,史静雯,雷凡,崔昭,刘梅芳,彭美玉..NF-κB信号通路在胰腺癌耐药机制中的研究进展[J].解放军医学杂志,2025,50(6):665-671,7.基金项目
This work was supported by the National Natural Science Foundation of China(81972695),the Introduction and Cultivation Program for Young Innovative Talents in Science and Technology Support Plan of Colleges and Universities in Shandong Province,and the Science and Technology Support Plan for Youth Innovation of Colleges and Universities of Shandong Province(2021KJ106) 国家自然科学基金(81972695) （81972695）
山东省高等学校青创人才引育计划 （）
山东省高等学校青创科技支持计划(2021KJ106) （2021KJ106）
