解放军医学杂志2025，Vol.50Issue(6)：679-687,9.DOI:10.11855/j.issn.0577-7402.0399.2024.1105
PD-L1的空间异质性研究进展
Research progress on the spatial heterogeneity of PD-L1
摘要
Abstract
Programmed death ligand-1(PD-L1),which is expressed on the surface of tumor cells,can bind to programmed death receptor-1(PD-1)on T cells.The interaction between PD-1 and PD-L1 can activate negative regulatory signal of T cells and inhibit their activation and proliferation,thus promoting tumor immune escape.PD-L1 is mainly expressed on the tumor cell membrane,but is also distributed in the nucleus,cytoplasm,and exosomes.Different spatial distribution of PD-L1 has different effects on tumors,among which the dynamic transformation and spatial heterogeneity expression of PD-L1 in tumors is the main reason for the unsatisfactory efficacy of PD-L1 antibodies.This article aims to introduce the spatial heterogeneity of PD-L1,and review the research progress on PD-L1 dynamic transformation in tumor cells,so as to provide new ideas for antitumor therapy based on PD-L1 antibody.关键词
肿瘤细胞/程序性死亡配体1/空间异质性/外泌体Key words
tumor cells/programmed death ligand-1/spatial heterogeneity/exosomes分类
生物科学引用本文复制引用
茹莉媛,郭微,余文丹..PD-L1的空间异质性研究进展[J].解放军医学杂志,2025,50(6):679-687,9.基金项目
This work was supported by the National Natural Science Foundation of China(82103122) 国家自然科学基金(82103122) （82103122）
