解放军医学杂志2025，Vol.50Issue(6)：709-715,7.DOI:10.11855/j.issn.0577-7402.0450.2024.1014
组织蛋白酶与甲状腺癌的因果关系:双样本孟德尔随机化分析
Assessment of causality between cathepsins and thyroid cancer:a two-sample Mendelian randomization
摘要
Abstract
Objective To investigate the causal relationship between cathepsin(CTS)and thyroid cancer by using Mendelian randomization(MR).Methods Aggregate data for CTS GWAS was obtained from the IEU Open Genome-wide Association Study(GWAS)database(https://gwas.mrcieu.ac.uk/),and thyroid cancer GWAS data was obtained from the EBI database(https://www.ebi.ac.uk/).Five different MR analysis methods were utilized,with the inverse variance-weighted method(IVW)as the main approach,complemented by the weighted median method,MR-Egger regression,simple mode method and weighted majority method.These methods were employed to analyze the relationship between 9 CTS genes and thyroid cancer through 9 double-sample analyses.MR-Egger intercept,MR-PRESSO for gene pleiotropy detection,Cochran Q test,and leave-one-out method were applied to assess pleiotropy and sensitivity,followed by reverse MR analysis.Results MR analysis showed that elevated level of CTS B was positively correlated with the risk of thyroid cancer(IVW OR=1.60,95%CI 1.12-2.30,P=0.01),while elevated CTS O level was negatively correlated with the risk of thyroid cancer(IVW OR=0.65,95%CI 0.45-0.95,P=0.02).Reverse MR analysis revealed no significant causal relationship between thyroid cancer and CTS B and CTS O(P>0.05).Conclusion CTS B may promote the development of thyroid cancer,whereas CTS O may inhibit its progression.关键词
甲状腺癌/组织蛋白酶/孟德尔随机化/生物标志物Key words
thyroid cancer/cathepsin/Mendelian randomization/biomarkers分类
医药卫生引用本文复制引用
连文静,孙小慧,梁爽,孙一华,孙子渊..组织蛋白酶与甲状腺癌的因果关系:双样本孟德尔随机化分析[J].解放军医学杂志,2025,50(6):709-715,7.基金项目
This work was supported by the Qilu Health Outstanding Youth Talent Project(Lu Health Personnel2020]No.3) 齐鲁卫生与健康杰出青年人才项目(鲁卫人字[2020]3号) （Lu Health Personnel2020]No.3）
