解剖学杂志2025，Vol.48Issue(3)：204-208,5.DOI:10.3969/j.issn.1001-1633.2025.03.004
肺癌组织USP39、HOXB13水平变化及其与患者临床病理特征和预后的关系
Changes in USP39 and HOXB13 levels in lung cancer tissues and their relationship with clinical pathological characteristics and prognosis of patients
摘要
Abstract
Objective:To investigate the changes in levels of ubiquitin-specific protease 39(USP39)and homeobox protein hox B13(HOXB13)in lung cancer tissues and their relationship with clinical pathological characteristics and prognosis of patients.Methods:A total of 102 cases of patients diagnosed with lung cancer in our hospital from August 2018 to August 2020 were collected.A three-year prognosis follow-up was conducted on the patients.ELISA method was applied to detect the levels of USP39 and HOXB13 in adjacent normal and lung cancer tissues.Immunohistochemical staining was adopted to detect the expression of USP39 and HOXB13 in adjacent normal and lung cancer tissues.Kaplan-Meier analysis was performed to analyze the relationship between USP39 and HOXB13 levels in lung cancer tissue and prognosis.COX regression was employed to analyze the influencing factors of prognosis in lung cancer.Results:The expression levels of USP39 and HOXB13 in the lung cancer group were obviously higher than the adjacent group.The positive expression rates of USP39 and HOXB13 in the lung cancer group were obviously higher than those in the adjacent group.The expression of USP39 and HOXB13 was correlated with clinical TNM staging,differentiation degree,and lymph node metastasis.Kaplan-Meier curve analysis showed that the survival rate of lung cancer patients with positive expression of USP39 and HOXB13 was obviously lower than that of patients with negative expression.COX analysis results showed that lymph node metastasis,USP39,and HOXB13 expression levels were prognostic factors for lung cancer patients.Conclusion:USP39 and HOXB13 are highly expressed in lung cancer tissues,which are associated with the clinical pathological characteristics and prognosis of patients.关键词
肺癌/泛素特异蛋白酶39/同源异形框B13/临床病理特征/预后Key words
lung cancer/ubiquitin-specific protease 39/homeobox protein hox B13/clinical pathological features/prognosis分类
医药卫生引用本文复制引用
王婧雯,张跃欣,郑大炜,郭娜,门翔..肺癌组织USP39、HOXB13水平变化及其与患者临床病理特征和预后的关系[J].解剖学杂志,2025,48(3):204-208,5.基金项目
河南省医学科技攻关项目(182102310184) （182102310184）
